CAJ | 학술논문

目的：探讨尿微量白蛋白（MA）、尿转铁蛋白（TRU）、尿免疫球蛋白（IgU）、尿α1-微球蛋白（α1- MG）和β2-微球蛋白（β2- MG）在糖尿病肾病（DN）早期诊断中的价值。方法将研究对象分为糖尿病肾病组和健康对照组，利用免疫散射速率比浊法测定尿特定蛋白含量，利用比浊法测定血、尿β2-微球蛋白含量，并进行分析。结果与健康对照组比较，糖尿病肾病患者尿微量白蛋白（MA）、尿转铁蛋白（TRU）、尿免疫球蛋白（IgU）、尿α1-微球蛋白（α1- MG）和β2-微球蛋白（β2- MG）含量和阳性率均显著增高，有显著性差异（ P ﹤0.05）；糖尿病肾病患者在早期检测中，尿微量蛋白的敏感度和特异度优于尿素和肌酐。结论联合检测尿特定蛋白和尿β2-微球蛋白可作为糖尿病肾病患者肾损害早期诊断的重要指标。
목적：탐토뇨미량백단백（MA）、뇨전철단백（TRU）、뇨면역구단백（IgU）、뇨α1-미구단백（α1- MG）화β2-미구단백（β2- MG）재당뇨병신병（DN）조기진단중적개치。방법장연구대상분위당뇨병신병조화건강대조조，이용면역산사속솔비탁법측정뇨특정단백함량，이용비탁법측정혈、뇨β2-미구단백함량，병진행분석。결과여건강대조조비교，당뇨병신병환자뇨미량백단백（MA）、뇨전철단백（TRU）、뇨면역구단백（IgU）、뇨α1-미구단백（α1- MG）화β2-미구단백（β2- MG）함량화양성솔균현저증고，유현저성차이（ P ﹤0.05）；당뇨병신병환자재조기검측중，뇨미량단백적민감도화특이도우우뇨소화기항。결론연합검측뇨특정단백화뇨β2-미구단백가작위당뇨병신병환자신손해조기진단적중요지표。
Objective To explore the early diagnostic value of urinary MA,TRU,IgU,α1 - MG and β2 - MG in patients with diabetic nephropathy. Methods All members for this study were divided into 2 groups:patients with diabetes nephritis group and healthy control group. Urine MA,TRU,IgU,α1 - MG and urine β2 - MG were tested. Results The levels of MA,TRU,IgU,α1 - MG and β2 - MG in blood and urine of patients with diabetes nephritis were markedly higher than those of healthy controls. The sensitivity and specificity of micro - protein in u-rine of patients with diabetes nephritis were higher than those of urea and creatinine. Conclnsion Combined detection of urine MA,TRU,IgG,α1 - MG and urine β2 - MG can serve as important indicators for early diagnosis of renal impairment in patients with diabetic nephropathy.