CAJ | 학술논문

目的：研究慢性乙肝患者规范抗病毒治疗后疗程与复发的相关性。方法所有病例均经规范使用核苷(酸)类药物治疗,停药后均随访104周；其中停药后继续巩固治疗1年的患者设为对照组,停药后继续巩固治疗3年的患者设为观察组,比较两组的复发率和复发时间。结果观察组停药后复发率明显低于对照组(χ2=3.877,P<0.05)。对照组38例,停药后复发31例,其中2周内复发2例,24周内复发25例,24周后复发4例,观察组30例,停药后复发18例,其中2周复发1例,24周内复发15例,24周后复发2例。结论延长抗病毒治疗时间能减少复发率,但未延长复发时间,因此,建议慢性乙肝患者使用核苷(酸)类药物治疗应严格依照有关指南用药,强调长期用药以维持疗效,并进行规范随防管理。
목적：연구만성을간환자규범항병독치료후료정여복발적상관성。방법소유병례균경규범사용핵감(산)류약물치료,정약후균수방104주；기중정약후계속공고치료1년적환자설위대조조,정약후계속공고치료3년적환자설위관찰조,비교량조적복발솔화복발시간。결과관찰조정약후복발솔명현저우대조조(χ2=3.877,P<0.05)。대조조38례,정약후복발31례,기중2주내복발2례,24주내복발25례,24주후복발4례,관찰조30례,정약후복발18례,기중2주복발1례,24주내복발15례,24주후복발2례。결론연장항병독치료시간능감소복발솔,단미연장복발시간,인차,건의만성을간환자사용핵감(산)류약물치료응엄격의조유관지남용약,강조장기용약이유지료효,병진행규범수방관리。
Objective To explore the relationship of course and recurrence after norms antiviral treatment for patients with chronic hepatitis B. Methods All cases were confirmed by standard use of nucleos drug treatment,after treatment,followed up for 104 weeks; patients after stopping the treatment and contiued to conslidate 1 year, set the control group,patients after stopping the treatment and tiued to consolidate 3 years, as observation group,the recurrence rates and recurrence time were compared. Results The relapse rate of observation group was significantly lower than the control group(χ2=3.877,P<0.05). Control group of 38 cases,31 cases of recurrence after treatment,included 2 cases of recurrence within 2 weeks,25 cases of recurrence within 24 weeks; 4 cases relapsed after 24 weeks.Observation group of 30 cases,18 cases of relapse after discontinuation,1 case relapsed in two weeks,15 cases of recurrence within 24 weeks,2 cases relapsed after treatment 24 weeks. Conclusion The prolonged antiviral therapy can reduce the recur-rence rate of the time,but did not extend the time to recurrence,we recommend patients with chronic hepatitis B nu-cleoside (acid) drug treatment medication should be strictly in accordance with the relevant guidelines,emphasizing long-term medication to maintain efficacy,And standardize management with antiviral treatment.