CAJ | 학술논문

目的：探讨母胎ABO血型不合孕妇中孕妇血型IgG抗体效价与围产儿溶血病(HDN)相关关系。方法以2011年9月~2014年2月于我院产科分娩的2137例血型不合产妇及其新生儿为研究对象,以产前最后一次血清IgG抗效价≥64为临床标准,生产后,对新生儿进行溶血病(HDN)相关指标检查,分析孕妇血型IgG抗体效价与围产儿溶血病(HDN)之间的相关关系以及危险因素。结果2137例ABO血型不合孕妇中有458例围产儿发生溶血病,随着产妇IgG抗体效价的不断增高,新生儿溶血病的发生率呈显著上升趋势,经过皮尔逊相关分析,相关系数为r=0.82,单因素分析发现,妊娠次数的增多、年龄增大、不良生育史等因素是导致新生儿发生溶血病(HDN)的独立危险因素。结论产前应加强对夫妇及胎儿的血型检查,及时对母胎ABO血型不合孕妇进行IgG抗体检测,尤其对高龄、多次妊娠以及有不良妊娠史的产妇严密监控,适当实施干预,尽力避免新生儿溶血病(HDN)的发生。
목적：탐토모태ABO혈형불합잉부중잉부혈형IgG항체효개여위산인용혈병(HDN)상관관계。방법이2011년9월~2014년2월우아원산과분면적2137례혈형불합산부급기신생인위연구대상,이산전최후일차혈청IgG항효개≥64위림상표준,생산후,대신생인진행용혈병(HDN)상관지표검사,분석잉부혈형IgG항체효개여위산인용혈병(HDN)지간적상관관계이급위험인소。결과2137례ABO혈형불합잉부중유458례위산인발생용혈병,수착산부IgG항체효개적불단증고,신생인용혈병적발생솔정현저상승추세,경과피이손상관분석,상관계수위r=0.82,단인소분석발현,임신차수적증다、년령증대、불량생육사등인소시도치신생인발생용혈병(HDN)적독립위험인소。결론산전응가강대부부급태인적혈형검사,급시대모태ABO혈형불합잉부진행IgG항체검측,우기대고령、다차임신이급유불량임신사적산부엄밀감공,괄당실시간예,진력피면신생인용혈병(HDN)적발생。
Objective To investigate the correlation between the blood type IgG antibody valence and the hemolytic disease of newborn (HDN) of the pregnancy women with maternal-fetal ABO blood type incompatibility. Methods 2137 pregnant women with blood type incompatibility who delivered in the obstetrical department of our hospital from September 2011 to February 2014 and their neonates were selected as the study subjects. The last serum IgG antibody valence equal to or greater than 64 served as the clinical standard. After birth, the neonates' HDN related indicators were examined. The correlation between pregnant women's blood type IgG antibody valence and HDN and the risk factors were analyzed. Results Of the 2137 pregnant women with ABO blood type incompatibility, 458 perinatal infants had hemolysis. As the pregnant women's IgG antibody valence increased, the incidence of HDN rose significantly;Pearson correlation analysis showed that the correlation coefficient was r=0.82. Univariate analysis found that increase of number of pregnancies, increase of age, poor childbearing history and other factors were independent risk factors of HDN. Conclusion Before birth, blood type examination of couples and fetuses should be enhanced, IgG antibody de-tection of pregnant women with maternal-fetal ABO blood type incompatibility should be conducted, the pregnant women with advanced age, multiple pregnancies and adverse pregnancy history should be monitored closely, and proper intervention should be implemented in order to avoid the occurrence of HDN.