CAJ | 학술논문

目的研究动脉瘤性蛛网膜下腔出血(aSAH)患者血清中可溶性细胞间黏附分-1(sICAM-1)含量动态变化规律，分析其与脑血管痉挛(CVS)发生的时项、程度的相关性。方法对40例动脉瘤性蛛网膜下腔出血患者(实验组)发病后1~3d(术前)、7~9d、11~13d血清中sICAM-1(用ELISA法进行检测)进行动态检测，用TCD检测大脑中动脉血流速度(VMCA )。结果动脉瘤性蛛网膜下腔出血患者血清中sICAM-1含量明显高于对照组，尤以发病后7~9d显著；患者脑血管痉挛程度越重，血清中sICAM-1含量越高。结论动脉瘤性蛛网膜下腔出血患者血清中的slCAM-1含量高低可以反映患者脑血管痉挛病情的严重程度，可以作为动脉瘤性蛛网膜下腔出血患者发病后脑血管痉挛病情判断、指导临床治疗及预后判断的有效指标。
목적연구동맥류성주망막하강출혈(aSAH)환자혈청중가용성세포간점부분-1(sICAM-1)함량동태변화규률，분석기여뇌혈관경련(CVS)발생적시항、정도적상관성。방법대40례동맥류성주망막하강출혈환자(실험조)발병후1~3d(술전)、7~9d、11~13d혈청중sICAM-1(용ELISA법진행검측)진행동태검측，용TCD검측대뇌중동맥혈류속도(VMCA )。결과동맥류성주망막하강출혈환자혈청중sICAM-1함량명현고우대조조，우이발병후7~9d현저；환자뇌혈관경련정도월중，혈청중sICAM-1함량월고。결론동맥류성주망막하강출혈환자혈청중적slCAM-1함량고저가이반영환자뇌혈관경련병정적엄중정도，가이작위동맥류성주망막하강출혈환자발병후뇌혈관경련병정판단、지도림상치료급예후판단적유효지표。
Objective To study the relationship between the serum concentration of sICAM-1with subarachnoid hemorrhage (aSAH) and the change of symptom,analysis its and cerebral vasospasm (CVS) of items,the degree of correlation.Methods Dynamical changes of the serum concentration of sICAM-1 during dif er days were observed in 40 cases with aSAH , TCD was used to measure VMCA ,and control group for the same period to our healthy adult physical examination of 20 cases. Results Al the indexes in 1~3 days, 7~9 days, 11~13 after aSAH were significantly dif erent ccmpared with those of the controls. The indexes of 7~9 days after aSAH were most significant;The higher the Hunt-Hess classification and grade of Fisher, the higher the serum content of sICAM-1; Degree of patients with cerebral vasospasm is heavier, the higher the serum content of sICAM-1.Conclusion This findings suggest that there be a positive correlation between the serum concentration of sICAM-1 and the change of symptom CVS.