CAJ | 학술논문

目的探讨Ⅲ胃癌手术联合术中植入缓释氟尿嘧啶(中人氟安)的可行性及疗效。方法分析我院2009年12月~2010年11月94例Ⅲ胃癌临床资料。94例均行胃癌根治术，术中分为两组；A治疗组，术中使用植入缓释氟尿嘧啶48例；B对照组，不植入缓释氟尿嘧啶46例。术后4w两组患者均采用静脉化疗，并作随访观察，行影像学以及实验学检查。结果使用植入缓释氟尿嘧啶患者腹腔引流液多，其中78.3%有腹痛、30.9%低热且腹痛，低热持续的时间均长于对照组(P<0.05)，但无其他明显毒副作用。治疗组与对照组相比术后1年内复发率(6.52%：16.25%)和死亡率(3.75%：10.91%)均有显著性差异(PP<0.05)。结论术中植入缓释氟尿嘧啶安全、可行，可降低Ⅲ胃癌术后1年复发率及提高术后1年生存率。
목적탐토Ⅲ위암수술연합술중식입완석불뇨밀정(중인불안)적가행성급료효。방법분석아원2009년12월~2010년11월94례Ⅲ위암림상자료。94례균행위암근치술，술중분위량조；A치료조，술중사용식입완석불뇨밀정48례；B대조조，불식입완석불뇨밀정46례。술후4w량조환자균채용정맥화료，병작수방관찰，행영상학이급실험학검사。결과사용식입완석불뇨밀정환자복강인류액다，기중78.3%유복통、30.9%저열차복통，저열지속적시간균장우대조조(P<0.05)，단무기타명현독부작용。치료조여대조조상비술후1년내복발솔(6.52%：16.25%)화사망솔(3.75%：10.91%)균유현저성차이(PP<0.05)。결론술중식입완석불뇨밀정안전、가행，가강저Ⅲ위암술후1년복발솔급제고술후1년생존솔。
Objective To assess the safety and ef ect of intraperitoneal chemotherapy with sustained-release-fluorouracil for patients with advanced gastric cancer.Methods 94 cases of gastric cancer underwent intraoperative treatment group divided into 2;groups A, fluorouracil sustained release implant surgery using 48 cases;B group, 46 cases without fluorouracil sustained release implant. Four weeks after two patients were treated with intravenous chemotherapy, and for fol ow-up observation, the line of imaging and laboratory studies. Results To use implantation of multi-fluorouracil in patients with peritoneal fluid drainage, which 78.3%had abdominal pain, fever and abdominal pain, 30.9%, fever duration were longer than the control group ( <0.05), but no other significant side ef ects. The treatment group compared with the control group recurrencerate within1-year (6.52%:16.25%) and mortality (3.75%:10.91%) were significantly dif erent ( <0.05).Conclusion Fluorouracil sustained release implant surgery is safe and feasible, can reduceⅢgastric cancer after 1-year recurrence rate and improve survival after 1-year, with some clinical value.