CAJ | 학술논문

目的观察免疫吸附血浆净化法治疗(IAPP)格林-巴利综合征(CGBS)的疗效。方法25例CGBS患者进行IAPP治疗，观察治疗前后神经功能改善情况，检测治疗前后血液中的免疫球蛋白、补体和总蛋白水平。结果25例患者共进行IAPP治疗108例次，平均每人治疗4.32次。治愈18例，有效7例，无效0例。与治疗前比较，治疗后患者血液中免疫球蛋白和补体均显著降低(均P﹤0.05)，而血浆总蛋白水平没有显著变化。结论免疫吸附血浆净化法治疗是治疗慢性格林巴利综合征有效的方法，可改善神经功能缺损状况，其机制与与降低血液中免疫球蛋白有关。
목적관찰면역흡부혈장정화법치료(IAPP)격림-파리종합정(CGBS)적료효。방법25례CGBS환자진행IAPP치료，관찰치료전후신경공능개선정황，검측치료전후혈액중적면역구단백、보체화총단백수평。결과25례환자공진행IAPP치료108례차，평균매인치료4.32차。치유18례，유효7례，무효0례。여치료전비교，치료후환자혈액중면역구단백화보체균현저강저(균P﹤0.05)，이혈장총단백수평몰유현저변화。결론면역흡부혈장정화법치료시치료만성격림파리종합정유효적방법，가개선신경공능결손상황，기궤제여여강저혈액중면역구단백유관。
Objective To observate the therapeutic ef icacy of immunoadsorption plasmapheresis (IAPP) in the Guil ain-Barre's syndrome (GBS) patients. Methods The twenty five cases GBS patients were healed with IAPP. The nerve function was observated after treatment with IAPP. The levels of blood immunoglobulin, complement and total protein were tested. Results The twenty five cases CGBS patients were treated with 108 times IAPP. The every patient was medially adopted 4.32 treatments. The eighteen cases were cured, the treatment was effective in seven cases patients and inefficacious treatment was zero cases. Compared with the pre-treatment, the levels of blood immunoglobulin and complement were significantly increased ( ﹤0.05) in post-treatment group.There were no significant dif erence about blood total protein between pre-treatment and post-treatment group.Conclusion The immunoadsorption plasmapheresis is therapeutic method for Guil ain-Barre's syndrome, which the neurologic impairment is significantly improved and the mechanism maybe is related with decrease of blood immunoglobulin.