CAJ | 학술논문

目的：探讨结直肠癌组织中干扰素诱导蛋白16（IFI16）表达与p53及p21waf1/cip表达间的相关性。方法免疫组化SP法检测56例不同病理组织分化结直肠癌标本IFI16、p53、p21waf1/cip的蛋白表达，Pearson等级相关分析法分析及其表达间的相关性。结果在结直肠癌细胞中IFI16除呈现胞核表达外，尚存在胞质的异位表达。 IFI16的表达与p21waf1/cip表达呈正相关（r＝0．365，P＜0．01），而异位的IFI16与p21waf1/cip表达呈负相关（r＝-0．298，P＜0．05）；IFI16的表达与p53表达无显著相关性（r＝0．056，P＞0．05）。结论 IFI16可能通过细胞表达及定位调控p21waf1/cip及其下游路径激活参与结直肠癌的发生、发展。
목적：탐토결직장암조직중간우소유도단백16（IFI16）표체여p53급p21waf1/cip표체간적상관성。방법면역조화SP법검측56례불동병리조직분화결직장암표본IFI16、p53、p21waf1/cip적단백표체，Pearson등급상관분석법분석급기표체간적상관성。결과재결직장암세포중IFI16제정현포핵표체외，상존재포질적이위표체。 IFI16적표체여p21waf1/cip표체정정상관（r＝0．365，P＜0．01），이이위적IFI16여p21waf1/cip표체정부상관（r＝-0．298，P＜0．05）；IFI16적표체여p53표체무현저상관성（r＝0．056，P＞0．05）。결론 IFI16가능통과세포표체급정위조공p21waf1/cip급기하유로경격활삼여결직장암적발생、발전。
Objective To study the expression and significance of IFI 16, p53 and p21waf1/cip in colorectal cancer tis-sues.Methods The SP immunohistochemistry method was applicated to detect the expression of IFI 16, p53 and p21waf1/cip in paraffin embedded blocks of colorectal cancer tissues .Results IFI16 was detected in nuclear and cytpoplasm of color-ectal cancer cell.The expression of IFI16 was positive correlated with p21waf1/cip (r=0.365, P<0.01), but the epitopic expression of IFI16 was negative correlated with p21waf1/cip(r=-0.298, P<0.05).There was no significant association between IFI16 and p53(P>0.05).Conclusion IFI16 might take part in the occurrence progress of colorectal cancer ac-cording to the expression and location of IFI 16 related with the p21waf1/cip .