CAJ | 학술논문

以肝素钠、氢氧化钾和氢氧化锌为主要原料，通过肝素化反应，制备抗凝血剂肝素锌钾复盐，探讨反应过程中pH值对产物中锌、钾离子浓度的影响规律，考察抗凝剂用量与体外凝血时间的关系，并对原料肝素钠和肝素锌钾复盐的抗凝血性能进行对比．实验结果显示，制备的肝素锌钾复盐的体外抗凝血时间为17 min，优于肝素钠的抗凝血性能；反应过程中pH值和抗凝剂的浓度对产物抗凝血性能影响显著，最佳pH值为3～4．
이간소납、경양화갑화경양화자위주요원료，통과간소화반응，제비항응혈제간소자갑복염，탐토반응과정중pH치대산물중자、갑리자농도적영향규률，고찰항응제용량여체외응혈시간적관계，병대원료간소납화간소자갑복염적항응혈성능진행대비．실험결과현시，제비적간소자갑복염적체외항응혈시간위17 min，우우간소납적항응혈성능；반응과정중pH치화항응제적농도대산물항응혈성능영향현저，최가pH치위3～4．
The heparin zinc potassium was prepared by heparinized reaction with heparin sodium , potassium hy-droxide and zinc hydroxide as main raw material .The effect of pH on the zinc ion and potassium ion concentra-tion in products was investigated , and the relationship between anticoagulant concentration and the coagulation time was observed .And the anticoagulant properties of heparin sodium and heparin zinc potassium were com -pared.The results show the coagulation time of heparin zinc potassium was 17 min, and the anticoagulant prop-erties of heparin zinc potassium were better than heparin sodium .The influences of pH and anticoagulant con-centration on anticoagulant properties were predominant , and the optimum pH value was 3~4 .