CAJ | 학술논문

目的：观察泮托拉唑联合铝碳酸镁治疗反流性咽喉炎的临床疗效。方法选取太和医院耳鼻咽喉门诊2010年2月至2014年2月就诊的90例反流性咽喉炎患者随机分为A组（泮托拉唑组）、B组（铝碳酸镁组）、C组（联合用药组），每组30例，治疗4周为1个疗程，比较3组患者临床疗效及各项指标变化。结果治疗1个疗程后，A组与B 组总有效率比较无明显差异（P＞0．05），C 组总有效率均显著高于A、B 组（P＜0．01）；3组患者治疗前反流症状指数量表（ RSI）和反流检查积分量表（ RFS）评分比较均无明显差异（ P＞0．05），治疗后RSI和RFS评分均较治疗前明显下降（P＜0．05），但A、B组与同期C组比较评分均有明显差异（P＜0．05）。结论泮托拉唑联合铝碳酸镁治疗反流性咽喉炎优于单一用药，值得推广。
목적：관찰반탁랍서연합려탄산미치료반류성인후염적림상료효。방법선취태화의원이비인후문진2010년2월지2014년2월취진적90례반류성인후염환자수궤분위A조（반탁랍서조）、B조（려탄산미조）、C조（연합용약조），매조30례，치료4주위1개료정，비교3조환자림상료효급각항지표변화。결과치료1개료정후，A조여B 조총유효솔비교무명현차이（P＞0．05），C 조총유효솔균현저고우A、B 조（P＜0．01）；3조환자치료전반류증상지수량표（ RSI）화반류검사적분량표（ RFS）평분비교균무명현차이（ P＞0．05），치료후RSI화RFS평분균교치료전명현하강（P＜0．05），단A、B조여동기C조비교평분균유명현차이（P＜0．05）。결론반탁랍서연합려탄산미치료반류성인후염우우단일용약，치득추엄。
Objective To observe the efficacy of treatment of pantoprazole with hydrotalcite for patients with laryngopharyngeal reflux .Methods From February 2010 to February 2014 ,90 cases of patients with laryn-gopharyngeal reflux ( LPRD) in the ENT outpatient department of TaiHe hospital were randomly divided into group A ( pantoprazole group ) , group B ( hydrotalcite group ) , group C ( combination therapy group ) .30 pa-tients in each group and were treated for 4 weeks for a course of treatment .Clinical efficacy and changes of ev-ery index of the three groups were analyzed .Results After a course of treatment , the total efficiency of group A and group B showed no significant difference ( P>0 .05 ) , but the total efficiency of group C was significantly higher than that of group A or group B ( P<0 .01 ) .The reflux symptom index ( RSI ) and the reflux finding score (RFS) were not significantly different before treatment ( P>0.05),while they were significantly de-creased after treatment (P<0.05).There were significant difference compared group C with group A and group B ( P<0 .05 ) .Conclusion Treatment of pantoprazole with hydrotalcite for LPRD is better than using single drug and it is worthy of clinical application .