湖北科技学院学报（医学版）
湖北科技學院學報（醫學版）
호북과기학원학보（의학판）
JOURNAL OF XIANNING UNIVERSITY (MEDICAL SCIENCES)
2014年
4期
285-288
,共4页
急性冠脉综合征%VCAM-1%ICAM-1%预后
急性冠脈綜閤徵%VCAM-1%ICAM-1%預後
급성관맥종합정%VCAM-1%ICAM-1%예후
Acute coronary syndrome%ICAM-1%VCAM-1%Prognosis
目的：探讨血清中可溶性细胞间粘附分子（ICAM-1）和血管细胞间粘附分子（VCAM-1）与急性冠脉综合征（ acute coronary syndrome ，ACS）及其预后的关系。方法选择120例确诊的ACS患者与120例年龄、性别匹配的健康人群作为研究对象，使用问卷调查搜集研究对象一般资料，同时随访ACS患者不良心脑血管事件（ MACCE）发生情况；使用全自动生化分析仪检测研究对象血清中总胆固醇、甘油三酯、血糖和超敏反应蛋白（hsCRP）水平，应用酶联免疫吸附法（ELISA）检测sVCAM-1和sICAM-1含量；分析VCAM-1和ICAM-1水平与ACS的关系。结果ACS患者血清sVCAM-1和sICAM-1水平显著高于对照组（P＜0．001），ACS患者中MACCE发生者血清sVCAM-1和sICAM-1水平也均显著高于非MACCE者（P＜0．001）；单因素及多因素Cox回归模型分析显示sVCAM-1是ACS患者发生MACCE的独立预测因素（单因素：RR＝4．63，95％CI：1．87-11．52，P＜0.001；多因素：RR＝4．88，95％CI：1．39-12．67，P＜0．001）。结论血清sVCAM-1水平可能与ACS发病有关，并且可以预测ACS患者的不良预后。
目的：探討血清中可溶性細胞間粘附分子（ICAM-1）和血管細胞間粘附分子（VCAM-1）與急性冠脈綜閤徵（ acute coronary syndrome ，ACS）及其預後的關繫。方法選擇120例確診的ACS患者與120例年齡、性彆匹配的健康人群作為研究對象，使用問捲調查搜集研究對象一般資料，同時隨訪ACS患者不良心腦血管事件（ MACCE）髮生情況；使用全自動生化分析儀檢測研究對象血清中總膽固醇、甘油三酯、血糖和超敏反應蛋白（hsCRP）水平，應用酶聯免疫吸附法（ELISA）檢測sVCAM-1和sICAM-1含量；分析VCAM-1和ICAM-1水平與ACS的關繫。結果ACS患者血清sVCAM-1和sICAM-1水平顯著高于對照組（P＜0．001），ACS患者中MACCE髮生者血清sVCAM-1和sICAM-1水平也均顯著高于非MACCE者（P＜0．001）；單因素及多因素Cox迴歸模型分析顯示sVCAM-1是ACS患者髮生MACCE的獨立預測因素（單因素：RR＝4．63，95％CI：1．87-11．52，P＜0.001；多因素：RR＝4．88，95％CI：1．39-12．67，P＜0．001）。結論血清sVCAM-1水平可能與ACS髮病有關，併且可以預測ACS患者的不良預後。
목적：탐토혈청중가용성세포간점부분자（ICAM-1）화혈관세포간점부분자（VCAM-1）여급성관맥종합정（ acute coronary syndrome ，ACS）급기예후적관계。방법선택120례학진적ACS환자여120례년령、성별필배적건강인군작위연구대상，사용문권조사수집연구대상일반자료，동시수방ACS환자불양심뇌혈관사건（ MACCE）발생정황；사용전자동생화분석의검측연구대상혈청중총담고순、감유삼지、혈당화초민반응단백（hsCRP）수평，응용매련면역흡부법（ELISA）검측sVCAM-1화sICAM-1함량；분석VCAM-1화ICAM-1수평여ACS적관계。결과ACS환자혈청sVCAM-1화sICAM-1수평현저고우대조조（P＜0．001），ACS환자중MACCE발생자혈청sVCAM-1화sICAM-1수평야균현저고우비MACCE자（P＜0．001）；단인소급다인소Cox회귀모형분석현시sVCAM-1시ACS환자발생MACCE적독립예측인소（단인소：RR＝4．63，95％CI：1．87-11．52，P＜0.001；다인소：RR＝4．88，95％CI：1．39-12．67，P＜0．001）。결론혈청sVCAM-1수평가능여ACS발병유관，병차가이예측ACS환자적불량예후。
Objective The purpose of this study was to investigate the relationship between serum ICAM-1, VCAM-1 level and acute coronary syndrome (ACS) prognosis.Methods A total of 120 hospitalized ACS patients and 120 age, sex matched healthy people with normal fasting serum were enrolled .The general information of object was collected by using the questionnaire survey and the occurrence of ACS patients with cardio cerebral vascular events (MACCE) was also followed up.Total cholesterol, triglycerides, glucose and hypersensitivity reaction protein ( hsCRP) level in serum were detected by using full automatic biochemical an-alyzer .The levels of sICAM-1 and sVCAM-1 were quantified by enzyme-linked immunosorbent assay .The sta-tistical analysis included chi square test , t test and Cox regression model .Results The expression levels of sI-CAM-1 and sVCAM-1 in ACS patients were significant higher than that of control group (P<0.001).The ex-pression levels of sICAM-1 and sVCAM-1 in ACS patients with MACCE were significant higher than that of pa-tients without MACCE ( P<0 .001 ) .COX regression analysis denied sVCAM-1 as an independent prognostic factor.Conclusion Our data suggest that sVCAM-1 may be associated with ACS risk , and it might serve as a biomarker for predicting ACS prognosis .
