湖北科技学院学报(医学版)
湖北科技學院學報(醫學版)
호북과기학원학보(의학판)
JOURNAL OF XIANNING UNIVERSITY (MEDICAL SCIENCES)
2014年
4期
280-282
,共3页
多西紫杉醇%人工晶体%疏水性%组织相容性
多西紫杉醇%人工晶體%疏水性%組織相容性
다서자삼순%인공정체%소수성%조직상용성
Docetaxel%IOL%Hydrophobicity%Biocompatibility
目的:探讨多西紫杉醇修饰的人工晶体对眼组织相容性的影响,为人工晶体的新型生物材料提供依据。方法通过空气等离子技术,用多西紫杉醇对疏水性人工晶体表面进行修饰处理。16只日本大耳白兔随机分为对照组和实验组,每组8只。对照组:手术植入疏水性人工晶体;实验组:手术植入表面经多西紫杉醇修饰后疏水性人工晶体。比较人工晶体经多西紫杉醇处理后和处理前其表面亲水性的变化,两组均在手术后24 h通过闪耀斑发生情况评估炎症感染程度,光镜下观察人工晶体周围组织炎症反应情况。结果通过对比多西紫杉醇处理前后的人工晶体亲水性改变,结果显示经过多西紫杉醇处理后晶体的亲水性明显增加,主要表现是接触角差异(78±6°VS 158±9°),与A组比较,B组的闪耀斑明显低于A组(230±10 VS 260±13);与A组比较,B组在术后24h植入的人工晶状体周围组织炎症细胞浸润计数结果明显低于A组(11±6 VS 103±22)。结论多西紫杉醇可通过等离子技术修饰人工晶体表面以增加其亲水性,进而增加了人工晶体和眼组织的组织相容性。
目的:探討多西紫杉醇脩飾的人工晶體對眼組織相容性的影響,為人工晶體的新型生物材料提供依據。方法通過空氣等離子技術,用多西紫杉醇對疏水性人工晶體錶麵進行脩飾處理。16隻日本大耳白兔隨機分為對照組和實驗組,每組8隻。對照組:手術植入疏水性人工晶體;實驗組:手術植入錶麵經多西紫杉醇脩飾後疏水性人工晶體。比較人工晶體經多西紫杉醇處理後和處理前其錶麵親水性的變化,兩組均在手術後24 h通過閃耀斑髮生情況評估炎癥感染程度,光鏡下觀察人工晶體週圍組織炎癥反應情況。結果通過對比多西紫杉醇處理前後的人工晶體親水性改變,結果顯示經過多西紫杉醇處理後晶體的親水性明顯增加,主要錶現是接觸角差異(78±6°VS 158±9°),與A組比較,B組的閃耀斑明顯低于A組(230±10 VS 260±13);與A組比較,B組在術後24h植入的人工晶狀體週圍組織炎癥細胞浸潤計數結果明顯低于A組(11±6 VS 103±22)。結論多西紫杉醇可通過等離子技術脩飾人工晶體錶麵以增加其親水性,進而增加瞭人工晶體和眼組織的組織相容性。
목적:탐토다서자삼순수식적인공정체대안조직상용성적영향,위인공정체적신형생물재료제공의거。방법통과공기등리자기술,용다서자삼순대소수성인공정체표면진행수식처리。16지일본대이백토수궤분위대조조화실험조,매조8지。대조조:수술식입소수성인공정체;실험조:수술식입표면경다서자삼순수식후소수성인공정체。비교인공정체경다서자삼순처리후화처리전기표면친수성적변화,량조균재수술후24 h통과섬요반발생정황평고염증감염정도,광경하관찰인공정체주위조직염증반응정황。결과통과대비다서자삼순처리전후적인공정체친수성개변,결과현시경과다서자삼순처리후정체적친수성명현증가,주요표현시접촉각차이(78±6°VS 158±9°),여A조비교,B조적섬요반명현저우A조(230±10 VS 260±13);여A조비교,B조재술후24h식입적인공정상체주위조직염증세포침윤계수결과명현저우A조(11±6 VS 103±22)。결론다서자삼순가통과등리자기술수식인공정체표면이증가기친수성,진이증가료인공정체화안조직적조직상용성。
Objective To study the influence of intraocular lens ( IOL) modified by Docetaxel to the bio-compatibility of ocular tissue in order to providing theoretical foundation for biological material .Methods The hydrophobicity IOL surface is pretreated by Docetaxel by the air plasma technique .32 rabbits were randomly di-vided into control group ( group A ) and experimental group ( group B ) .Rabbits in Group A received conven-tional IOL through the general surgery , while rabbits in group B received the IOL pretreated by Docetaxel 24 hours after the operation , the inflammation was assessed by aqueous flare measurement in two groups .The in-flammation of surrounding tissue was observed under light microscope .Results Compared the IOL pretreated by Docetaxel and the general IOL using the contact-angle goniometer , the result show that the former IOL contact angle decreased significantly .Compared with group A , aqueous flare in group B decreased significantly ,and the infiltration of the inflammatory cells also decreaseed significantly .Conclusoi n Docetaxel could improve biocom-patibility between the intraocular lens and the ocular tissue .