CAJ | 학술논문

目的：探讨鼠神经生长因子对一氧化碳中毒迟发性脑病患者认知功能及日常生活活动能力的影响。方法一氧化碳中毒迟发型脑病患者35例随机分为治疗组(n=18)和对照组(n=17)。两组均接受系统高压氧治疗和药物治疗，治疗组在此基础上行鼠神经生长因子治疗。治疗前及治疗12周后，分别采用洛文斯顿作业疗法认知评定量表(LOTCA)、改良Barthel指数(MBI)对患者进行评定。结果治疗后，治疗组LOTCA、MBI评分改善优于对照组(P<0.05)。结论鼠神经生长因子可有效改善一氧化碳中毒迟发性脑病患者的认知功能，提高其日常生活活动能力。
목적：탐토서신경생장인자대일양화탄중독지발성뇌병환자인지공능급일상생활활동능력적영향。방법일양화탄중독지발형뇌병환자35례수궤분위치료조(n=18)화대조조(n=17)。량조균접수계통고압양치료화약물치료，치료조재차기출상행서신경생장인자치료。치료전급치료12주후，분별채용락문사돈작업요법인지평정량표(LOTCA)、개량Barthel지수(MBI)대환자진행평정。결과치료후，치료조LOTCA、MBI평분개선우우대조조(P<0.05)。결론서신경생장인자가유효개선일양화탄중독지발성뇌병환자적인지공능，제고기일상생활활동능력。
Objective To observe the effect of mouse nerve growth factor (mNGF) on cognitive function and activities of daily living (ADL) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods 35 patients with delayed encephalopathy after acute carbon monoxide poisoning were randomly divided into treatment group (n=18) and control group (n=18). Both groups accepted hyperbaric oxygen and medication, while the treatment group was injected with mNGF 20 mg a day in addition for 12 weeks. They were as-sessed with Loewenstein Occupational Therapy Cognitive Asessment (LOTCA) and modified Barthel Index (MBI) before and after treat-ment. Results The scores of LOTCA and MBI improved more in the treatment group than in the control group after treatment (P<0.05). Conclusion mNGF can obviously improve cognitive function and ADL for patients with delayed encephalopathy after acute carbon monox-ide poisoning.