CAJ | 학술논문

脑膜转移是肺癌最严重的并发症之一，患者预后极差。脑膜转移患者临床表现缺乏特异性，主要表现为脑、脑神经、脊神经受累症状。目前诊断主要依据肿瘤病史、临床症状、增强核磁共振（magnetic resnance image, MRI）扫描和脑脊液细胞学检查。近年来新的检测方式在临床上不断涌现，明显提高了脑膜转移的早期发现率，但肺癌脑膜转移的综合治疗疗效仍不令人满意。本文就肺癌脑膜转移的病理生理、临床表现、诊断方法及治疗疗效的研究进展做一综述。
뇌막전이시폐암최엄중적병발증지일，환자예후겁차。뇌막전이환자림상표현결핍특이성，주요표현위뇌、뇌신경、척신경수루증상。목전진단주요의거종류병사、림상증상、증강핵자공진（magnetic resnance image, MRI）소묘화뇌척액세포학검사。근년래신적검측방식재림상상불단용현，명현제고료뇌막전이적조기발현솔，단폐암뇌막전이적종합치료료효잉불령인만의。본문취폐암뇌막전이적병리생리、림상표현、진단방법급치료료효적연구진전주일종술。
Leptomeningeal metastases is one of the most serious complications of lung cancer, the patients with poor prognosis. Leptomeningeal metastasis in patients with lack speciifcity of clinical manifestations. hTe main clinical perfor-mance are the damage of cerebral symptoms, cranial nerve and spinal nerve. hTe diagnosis primarily based on the history of tumor, clinical symptoms, enhance magnetic resnance image (MRI) scan and cerebrospinal lfuid cytology. In recent years, new ways of detecting clinically, signiifcantly increase the rate of early detection of leptomeningeal metastases. hTe effect of compre-hensive treatments are still sad. hTe paper make a review of research progress in pathologic physiology, clinical manifestations, diagnosis methods and treatments of lung cancer with leptomeningeal metastases.