中国肺癌杂志
中國肺癌雜誌
중국폐암잡지
CHINESE JOURNAL OF LUNG CANCER
2014年
9期
685-688
,共4页
陈雪琴%杨邵瑜(综述)%马胜林(审校)
陳雪琴%楊邵瑜(綜述)%馬勝林(審校)
진설금%양소유(종술)%마성림(심교)
肺肿瘤%靶向药物%肝脏毒性
肺腫瘤%靶嚮藥物%肝髒毒性
폐종류%파향약물%간장독성
Lung neoplasms%Targeted drugs%Hepatotoxicity
针对驱动基因的靶向药物吉非替尼、厄洛替尼及克唑替尼等在晚期非小细胞肺癌治疗中有着不可替代的地位，然而此类药物给患者带来益处的同时也出现较高的肝脏毒性，现就其肝脏毒性及机制作一综述。
針對驅動基因的靶嚮藥物吉非替尼、阨洛替尼及剋唑替尼等在晚期非小細胞肺癌治療中有著不可替代的地位，然而此類藥物給患者帶來益處的同時也齣現較高的肝髒毒性，現就其肝髒毒性及機製作一綜述。
침대구동기인적파향약물길비체니、액락체니급극서체니등재만기비소세포폐암치료중유착불가체대적지위，연이차류약물급환자대래익처적동시야출현교고적간장독성，현취기간장독성급궤제작일종술。
Targeted drugs aimed at driver gene, such as Geiftinib, Erlotinib and Crizotinib, have an irreplaceable position in the therapy of advanced non-small cell lung cancer. hTese drugs bring beneift to patients, however, higher hepato-toxicity is also presented. Now, drug induced hepatotoxicity and its mechanism are reviewed.
