CAJ | 학술논문

microRNAs是一类非蛋白质编码性小RNA分子，参与调控目的基因的转录后水平，影响骨骼肌细胞的增殖、分化、肥大、凋亡等生物学过程。c-microRNAs 是从细胞分泌进入血液循环的microRNAs。最近研究表明，c-microRNAs 调控骨骼肌的生理、病理功能，包括急、慢性运动后适应性显型变化过程。因此，关于运动与 microRNAs 的关系，尤其是 c-mi-croRNAs在运动中的变化引起学者们的普遍关注。介绍了骨骼肌 microRNAs、c-microRNAs及其在运动性骨骼肌显型变化中的调控作用，深入探讨 c-microRNAs对骨骼肌显型变化的影响。阐明以c-microRNAs作为生化标志物，与肌肉相关的生理和病理变化的关系，更全面揭示运动性骨骼肌显型变化的分子机理，进一步丰富运动适应的细胞信号调控理论及与肌肉相关疾病的病理分子机制，同时为运动性疲劳、运动风险发生率和运动性疾病的发生、发展防治策略提出新的观点。
microRNAs시일류비단백질편마성소RNA분자，삼여조공목적기인적전록후수평，영향골격기세포적증식、분화、비대、조망등생물학과정。c-microRNAs 시종세포분비진입혈액순배적microRNAs。최근연구표명，c-microRNAs 조공골격기적생리、병리공능，포괄급、만성운동후괄응성현형변화과정。인차，관우운동여 microRNAs 적관계，우기시 c-mi-croRNAs재운동중적변화인기학자문적보편관주。개소료골격기 microRNAs、c-microRNAs급기재운동성골격기현형변화중적조공작용，심입탐토 c-microRNAs대골격기현형변화적영향。천명이c-microRNAs작위생화표지물，여기육상관적생리화병리변화적관계，경전면게시운동성골격기현형변화적분자궤리，진일보봉부운동괄응적세포신호조공이론급여기육상관질병적병리분자궤제，동시위운동성피로、운동풍험발생솔화운동성질병적발생、발전방치책략제출신적관점。
miRNAs are a group of small non protein-coding RNAs that regulate target gene ex-pression by translational repression and target mRNA degradation and affect proliferation ,dif-ferentiation ,hypertrophy and apoptosis of skeletal muscle .c-microRNAs refer those microR-NAs from cells secreting into blood circulation ,they also regulate skeletal muscle physiology and pathology conditions ,including acute and chronic exercise related phenotype changes .This paper mainly focuses on skeletal muscle- specific microRNAs ,c-microRNAs and their role in regulating exercise induced skeletal muscle phenotype change ,and clarifies the role of c-mi-croRNAs as biomarkers in physiological and pathological conditions .Further understanding the molecular mechanism of exercise-induced skeletal muscle phenotype changes fully will enrich the cell signal theory and pathological molecular mechanisms related muscle diseases .In addi-tion ,it can put forward new ideas for sports fatigue ,sport incidence and prevention strategies related exercise-induced diseases .