CAJ | 학술논문

游离脂肪酸（free fatty acids， FFA）是脂肪的代谢产物，能刺激中性粒细胞产生活性氧，如过氧化氢和次氯酸。研究表明FFA与心肌、血管内皮、肝、肺等组织损伤密切相关。红细胞损伤的机制则是细胞膜表面的多不饱和脂肪酸和胞内血红蛋白受到活性氧的氧化过程。高浓度FFA可导致高活性反应分子氧簇活性氧生成增多，从而启动了氧化应激机制，活性分子可直接氧化和损伤脫氧核醣核酸、蛋白质、脂类等分子。文中综述近年来对FFA与红细胞损伤之间相关性的研究进展，为研究氧化性贫血提供新方向。
유리지방산（free fatty acids， FFA）시지방적대사산물，능자격중성립세포산생활성양，여과양화경화차록산。연구표명FFA여심기、혈관내피、간、폐등조직손상밀절상관。홍세포손상적궤제칙시세포막표면적다불포화지방산화포내혈홍단백수도활성양적양화과정。고농도FFA가도치고활성반응분자양족활성양생성증다，종이계동료양화응격궤제，활성분자가직접양화화손상탈양핵당핵산、단백질、지류등분자。문중종술근년래대FFA여홍세포손상지간상관성적연구진전，위연구양화성빈혈제공신방향。
Free fatty acids generated from the metabolites of fat have been demonstrated to stimulate the neutrophils to produce reactive oxygen species ( ROS) such as hydrogen peroxide and chlorous peroxide .It has shown that free fatty acid is closely related with myocardial, vascular endothelium, liver, lung and other tissue damage.The mechanism of erythrocyte injury is oxidation of mem-brane polyunsaturated fatty acids and cytosolic hemoglobin by ROS .High levels of free fatty acids can increase the formation of active reaction molecular ROS , thus initiating the oxidative stress reaction .Active molecules can oxalate and damage the DNA , protein, lipid and other molecules of RBC .It has revealed the relationship between free fatty acids and erythrocytes injury , which provided a new di-rection in the research of oxidative anemia .This article reviews the advances in the research of this subject in recent years .