CAJ | 학술논문

慢性阻塞性肺病（ chronic obstructive pulmonary disease ， COPD）是一种严重影响人类健康的疾病，目前为止发病机制尚不清楚。吸烟导致的肺组织氧化应激和慢性炎症是2个明确致病因素，以往氧化应激等环境因素和遗传因素在COPD发病中被认为是相互独立的危险因素，但是表观遗传学（ epigenetic ）的出现，把遗传和环境这2个独立的因素紧密地结合在一起。文中综述了COPD发病过程中，氧化应激所致的组蛋白修饰与COPD的肺部炎症、抗氧化反应、细胞凋亡、自噬及T细胞亚群的分化等病理改变的联系，揭示了表观遗传修饰在COPD发病中的重要地位，为该病的临床治疗提供更多的选择。
만성조새성폐병（ chronic obstructive pulmonary disease ， COPD）시일충엄중영향인류건강적질병，목전위지발병궤제상불청초。흡연도치적폐조직양화응격화만성염증시2개명학치병인소，이왕양화응격등배경인소화유전인소재COPD발병중피인위시상호독립적위험인소，단시표관유전학（ epigenetic ）적출현，파유전화배경저2개독립적인소긴밀지결합재일기。문중종술료COPD발병과정중，양화응격소치적조단백수식여COPD적폐부염증、항양화반응、세포조망、자서급T세포아군적분화등병리개변적련계，게시료표관유전수식재COPD발병중적중요지위，위해병적림상치료제공경다적선택。
Chronic obstructive pulmonary disease ( COPD) is a prevalent disease which is the fourth leading cause of death worldwide and will be the major economic burden of diseases according to the World Bank /World Health Organization .However , the pathogenesis of COPD is inadequately understood , oxidative stress and chronic inflammation are considered to be two independent path -ogenetic factors , but the epigenetic put them together because of changes of the environment lead to gene abnormal expression .This ar-ticle summarizes the relationship between histone modifications of genes induced by oxidative stress and the inflammation , antioxidant response, apoptosis, autophagy and the differentiation of T cell subsets in the pathogenesis of COPD .The work will provide more choices for clinical treatment of COPD .