医学研究生学报
醫學研究生學報
의학연구생학보
JOURNAL OF MEDICAL POSTGRADUATE
2014年
9期
936-939
,共4页
黄志新%侯华娟%周小龙%段作伟%张晓浩%李壮丽%樊小兵
黃誌新%侯華娟%週小龍%段作偉%張曉浩%李壯麗%樊小兵
황지신%후화연%주소룡%단작위%장효호%리장려%번소병
脑微出血%缺血性卒中%E选择素
腦微齣血%缺血性卒中%E選擇素
뇌미출혈%결혈성졸중%E선택소
Cerebral microbleeds%Ischemic stroke%E-selectin
目的:脑微出血(cerebral microbleeds, CMBs)是脑小血管病的重要表现之一,但与内皮功能紊乱之间是否存在相关性仍不明确。文中探讨CMBs与可溶性E选择素(简称sE-选择素)的相关性。方法连续入组首次急性缺血性卒中的患者,进行3.0T MRI磁敏感加权成像(susceptibility weighted imaging , SWI)检查,在脑梗死患者的基础上根据有无CMBs分为CMBs组和非CMBs组各63例;选择同期门诊体检人员经MRI检查无异常者45例作为对照组。详细记录各组患者的人口统计学资料、血液学指标(包括血清sE-选择素水平)、血管危险因素和SWI序列显示的CMBs数量,进行比较和分析。结果最终入组171例受试者,有序Logistic回归分析显示,sE-选择素与CMBs数量显著正相关(OR=1.062,95%CI:1.023~1.103,P=0.002);收缩压越高CMBs数量越多(OR=1.014,95%CI:1.002~1.025,P=0.021)。结论 sE-选择素与CMBs严重程度正相关,或许可作为评价CMBs严重性的生物指标之一。
目的:腦微齣血(cerebral microbleeds, CMBs)是腦小血管病的重要錶現之一,但與內皮功能紊亂之間是否存在相關性仍不明確。文中探討CMBs與可溶性E選擇素(簡稱sE-選擇素)的相關性。方法連續入組首次急性缺血性卒中的患者,進行3.0T MRI磁敏感加權成像(susceptibility weighted imaging , SWI)檢查,在腦梗死患者的基礎上根據有無CMBs分為CMBs組和非CMBs組各63例;選擇同期門診體檢人員經MRI檢查無異常者45例作為對照組。詳細記錄各組患者的人口統計學資料、血液學指標(包括血清sE-選擇素水平)、血管危險因素和SWI序列顯示的CMBs數量,進行比較和分析。結果最終入組171例受試者,有序Logistic迴歸分析顯示,sE-選擇素與CMBs數量顯著正相關(OR=1.062,95%CI:1.023~1.103,P=0.002);收縮壓越高CMBs數量越多(OR=1.014,95%CI:1.002~1.025,P=0.021)。結論 sE-選擇素與CMBs嚴重程度正相關,或許可作為評價CMBs嚴重性的生物指標之一。
목적:뇌미출혈(cerebral microbleeds, CMBs)시뇌소혈관병적중요표현지일,단여내피공능문란지간시부존재상관성잉불명학。문중탐토CMBs여가용성E선택소(간칭sE-선택소)적상관성。방법련속입조수차급성결혈성졸중적환자,진행3.0T MRI자민감가권성상(susceptibility weighted imaging , SWI)검사,재뇌경사환자적기출상근거유무CMBs분위CMBs조화비CMBs조각63례;선택동기문진체검인원경MRI검사무이상자45례작위대조조。상세기록각조환자적인구통계학자료、혈액학지표(포괄혈청sE-선택소수평)、혈관위험인소화SWI서렬현시적CMBs수량,진행비교화분석。결과최종입조171례수시자,유서Logistic회귀분석현시,sE-선택소여CMBs수량현저정상관(OR=1.062,95%CI:1.023~1.103,P=0.002);수축압월고CMBs수량월다(OR=1.014,95%CI:1.002~1.025,P=0.021)。결론 sE-선택소여CMBs엄중정도정상관,혹허가작위평개CMBs엄중성적생물지표지일。
Objective Cerebral microbleeds (CMBs) are important indicators of cerebral small vessel disease .However, it is still unclear whether endothelial dysfunction is involved in CMBs .The aim of this study is to investigate the correlation between CMBs and soluble E-selectin (sE-selectin) in patients with acute ischemic stroke . Methods Based on the results of MRI (3.0 T) susceptibility weighted imaging , we divided patients with first acute ischemic stroke into a CMBs group ( n=63 ) and a non-CMBs group (n=63), and recruited another 45 volunteers with normal MRI findings as controls .We collected and conducted comparative a-nalysis on the demographic data , biochemical variables ( including the sE-selectin level ) , vascular risk factors , and the number of CMBs of the patients . Results Ordinal logistic regression analysis showed a significantly positive correlation between sE -selectin and the number of CMBs (OR=1.062, 95%CI:1.023-1.103, P=0.002), higher systolic blood pressure associated with more CMBs (OR=1.014, 95%CI:1.002-1.025, P=0.021). Conclusion Serum sE-selectin is significantly positively correlated with and can be used as a biological marker for the severity of CMBs .