河北中医
河北中醫
하북중의
HEBEI JORNAL OF TRADITIONAL CHINESE MEDICINE
2014年
10期
1543-1545
,共3页
吕立勋%李唐棣%赵琳琳%赵利刚%吴范武
呂立勛%李唐棣%趙琳琳%趙利剛%吳範武
려립훈%리당체%조림림%조리강%오범무
疾病模型,动物%糖尿病%胰岛素抗药性%中药疗法%黄芩
疾病模型,動物%糖尿病%胰島素抗藥性%中藥療法%黃芩
질병모형,동물%당뇨병%이도소항약성%중약요법%황금
Disease models%Animal%Diabetes%Insulin resistance%Traditional Chinese medicine therapy%Scutellaria baicalensis
目的:观察三清降糖缓释片对糖尿病兔胰岛素抵抗的影响。方法将40只健康成年雄性家兔随机分为5组,即空白对照组、模型对照组、格列美脲片组、三清降糖汤剂组和三清降糖缓释片组,每组8只。空白对照组予普通饲料喂养,其余4组均予普通饲料+高脂高糖饲料喂养,制备糖尿病模型。空白对照组、模型对照组予纯净水灌胃,三清降糖汤组予三清降糖汤混悬液灌胃,三清降糖缓释片组予三清降糖缓释片整片服用,格列美脲片组予格列美脲片整片服用。于给药4周末,观察各组空腹血糖( FPG)、血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血清胰岛素(FINS)及肿瘤坏死因子α(TNF-α)变化。结果模型对照组FPG、FINS、胰岛素抵抗指数(HOMA-IR)及TNF-α均较空白对照组升高(P<0.01),说明造模成功;与模型对照组比较,格列美脲片组、三清降糖汤组及三清降糖缓释片组FPG、FINS、HOMA-IR及TNF-α均下降(P<0.05)。模型对照组TG、TC及LDL-C均高于空白对照组(P<0.01),HDL-C低于空白对照组(P<0.01)。与模型对照组比较,格列美脲片组、三清降糖汤组及三清降糖缓释片组TG、TC及LDL-C 均降低(P<0.05),HDL-C升高(P<0.05)。结论三清降糖缓释片对糖尿病兔具有降血糖、降血脂作用。
目的:觀察三清降糖緩釋片對糖尿病兔胰島素牴抗的影響。方法將40隻健康成年雄性傢兔隨機分為5組,即空白對照組、模型對照組、格列美脲片組、三清降糖湯劑組和三清降糖緩釋片組,每組8隻。空白對照組予普通飼料餵養,其餘4組均予普通飼料+高脂高糖飼料餵養,製備糖尿病模型。空白對照組、模型對照組予純淨水灌胃,三清降糖湯組予三清降糖湯混懸液灌胃,三清降糖緩釋片組予三清降糖緩釋片整片服用,格列美脲片組予格列美脲片整片服用。于給藥4週末,觀察各組空腹血糖( FPG)、血脂[總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)]、血清胰島素(FINS)及腫瘤壞死因子α(TNF-α)變化。結果模型對照組FPG、FINS、胰島素牴抗指數(HOMA-IR)及TNF-α均較空白對照組升高(P<0.01),說明造模成功;與模型對照組比較,格列美脲片組、三清降糖湯組及三清降糖緩釋片組FPG、FINS、HOMA-IR及TNF-α均下降(P<0.05)。模型對照組TG、TC及LDL-C均高于空白對照組(P<0.01),HDL-C低于空白對照組(P<0.01)。與模型對照組比較,格列美脲片組、三清降糖湯組及三清降糖緩釋片組TG、TC及LDL-C 均降低(P<0.05),HDL-C升高(P<0.05)。結論三清降糖緩釋片對糖尿病兔具有降血糖、降血脂作用。
목적:관찰삼청강당완석편대당뇨병토이도소저항적영향。방법장40지건강성년웅성가토수궤분위5조,즉공백대조조、모형대조조、격렬미뇨편조、삼청강당탕제조화삼청강당완석편조,매조8지。공백대조조여보통사료위양,기여4조균여보통사료+고지고당사료위양,제비당뇨병모형。공백대조조、모형대조조여순정수관위,삼청강당탕조여삼청강당탕혼현액관위,삼청강당완석편조여삼청강당완석편정편복용,격렬미뇨편조여격렬미뇨편정편복용。우급약4주말,관찰각조공복혈당( FPG)、혈지[총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)]、혈청이도소(FINS)급종류배사인자α(TNF-α)변화。결과모형대조조FPG、FINS、이도소저항지수(HOMA-IR)급TNF-α균교공백대조조승고(P<0.01),설명조모성공;여모형대조조비교,격렬미뇨편조、삼청강당탕조급삼청강당완석편조FPG、FINS、HOMA-IR급TNF-α균하강(P<0.05)。모형대조조TG、TC급LDL-C균고우공백대조조(P<0.01),HDL-C저우공백대조조(P<0.01)。여모형대조조비교,격렬미뇨편조、삼청강당탕조급삼청강당완석편조TG、TC급LDL-C 균강저(P<0.05),HDL-C승고(P<0.05)。결론삼청강당완석편대당뇨병토구유강혈당、강혈지작용。
Objective To observe the effect of sustained -release Sanqingjiangtang tablets on insulin resist-ance in diabetic rabbits .Methods To induce diabetes in healthy male rabbits by high fat sugar and high salt diet , and then inject streptozotocin (STZ).50 healthy male rabbits were divided into5 groups randomly, control group, model group , glimepiride group ,Sanqingjiangtang decoction and sustained -release tablets group .Intragastric admin-istration of the corresponding drugs respectively for 4 weeks,and then measuring blood glucose , blood lipid, insulin, TNF-αand calculating HOMA -IR.Results FPG, FINS, HOMA-IR and TNF-αin model group were in-creased as compared with those in control group (P<0.01).FPG, FINS, HOMA-IR and TNF-αin glimepiride group,Sanqingjiangtang decoction and sustained -release tablets group were decreased as compared with those in model group (P<0.05).The levels of TG, TC and LDL-C in model group were higher than those in control group (P<0.01).HDL-C in model group was lower (P<0.01).The levels of TG, TC and LDL-C in glimepiride group,Sanqingjiangtang decoction and sustained -release tablets group were lower than those in model group ( P<0.05).HDL-C was higher (P<0.05).Conclusion Sanqingjiangtang sustained -release tablets can significantly decrease blood lipid and glucose in diabetic rabbits .