CAJ | 학술논문

目的：探讨阿立哌唑联用氯氮平维持治疗对慢性精神分裂症患者认知功能的影响。方法：入组40例维持期的慢性精神分裂症患者，均为阿立哌唑联用氯氮平治疗(联用组)，与同期住院的40例单用氯氮平治疗的慢性精神分裂症患者(单用组)对照。分别于入组时、入组后6个月、12个月采用重复性成套神经心理状态测验( RBANS)评定患者的认知功能，并同时用PANSS量表评定患者的临床疗效，副反应量表(TESS)评定药物不良反应。结果：PANSS总评分入组时、入组后12个月两组患者之间差异无统计学意义(P>0.05)，各组患者治疗前后差异也无统计学意义(P>0.05)。认知功能评定联用组患者入组后6个月开始注意功能因子分，即刻记忆因子分与入组前相比差异有统计学意义(P<0.05)，其它视觉广度、言语功能、延迟记忆因子分入组前后差异无统计学意义(P>0.05)，单用组患者5项因子分入组前后差异均无统计学意义(P>0.05)。总不良反应两组患者间差异有统计学意义(P<0.05)。结论：阿立哌唑联用氯氮平维持治疗是一种安全有效的治疗方法，能部分改善患者的认知功能障碍，不良反应小。
목적：탐토아립고서련용록담평유지치료대만성정신분렬증환자인지공능적영향。방법：입조40례유지기적만성정신분렬증환자，균위아립고서련용록담평치료(련용조)，여동기주원적40례단용록담평치료적만성정신분렬증환자(단용조)대조。분별우입조시、입조후6개월、12개월채용중복성성투신경심리상태측험( RBANS)평정환자적인지공능，병동시용PANSS량표평정환자적림상료효，부반응량표(TESS)평정약물불량반응。결과：PANSS총평분입조시、입조후12개월량조환자지간차이무통계학의의(P>0.05)，각조환자치료전후차이야무통계학의의(P>0.05)。인지공능평정련용조환자입조후6개월개시주의공능인자분，즉각기억인자분여입조전상비차이유통계학의의(P<0.05)，기타시각엄도、언어공능、연지기억인자분입조전후차이무통계학의의(P>0.05)，단용조환자5항인자분입조전후차이균무통계학의의(P>0.05)。총불량반응량조환자간차이유통계학의의(P<0.05)。결론：아립고서련용록담평유지치료시일충안전유효적치료방법，능부분개선환자적인지공능장애，불량반응소。
Objective:To discuss influence of Aripiprazole combined with Clozapine on cognitive function in maintenance treat-ment of chronic schizophrenic patients. Methods:40 admitted schizophrenic patients in maintenance stage, who were all treated by u-sing Aripiprazole combined with Clozapine, were used as combination group, whilethe other 40 admitted schizophrenia patients at the same time, who were treated by Clozapine, were chosen as single group. Their cognitive functions were assess by repeatable battery for the assessment of neuropsychological status ( RBANS) , the clinical effects were evaluated by PANSS, and adverse drug reactions were assessed by treatment emergent symptom scale ( TESS) at admission and 6 and 12 months after admission. Results:There were no sta-tistical differences in the total scores of PANSS at admission and 12 months after admission between the two groups (P>0. 05). There were no statistical differences for the two groups before and after the treatment (P>0. 05). In the assessment of cognitive function, the combination group began to pay attention to functional factor scores, and the immediate memorial factor score difference had the statisti-cal significance before and after admission (P<0. 05). There were no statistical differences in the scores of visual span, speech func-tion and delayed memorial factor for combination group before and after admission (P>0. 05). 5 factor scores of single group all had no statistical differences before and after admission (P>0. 05). The differences in the total adverse reactions between the two groups had the statistical significance (P<0. 05). Conclusions:Aripiprazole combined with Clozapine for the maintenance treatment is a safe and effective method, which can improve the patients' cognitive functional disorder with little adverse reactions.