CAJ | 학술논문

目的：比较晚期前列腺癌患者分别采用国产亮丙瑞林药物去势与手术去势治疗的疗效和安全性。方法：60例患者随机采用国产亮丙瑞林药物去势或手术去势，并联合比卡鲁胺行全雄激素阻断，观察两种治疗方法的疗效及不良反应。结果：药物去势组与手术去势组的有效率分别为86.6%和83.3%（P>0.05），90%药物去势和93%手术去势患者的血清睾酮水平经6个月治疗后维持在去势水平。两组治疗相关不良反应主要表现为潮热、乳房胀痛、疲劳等，两组无统计学差异，但注射部位疼痛为药物去势所特有。结论：国产亮丙瑞林药物去势与手术去势相比，短期疗效确切，不良反应小，能改善患者的生活质量。
목적：비교만기전렬선암환자분별채용국산량병서림약물거세여수술거세치료적료효화안전성。방법：60례환자수궤채용국산량병서림약물거세혹수술거세，병연합비잡로알행전웅격소조단，관찰량충치료방법적료효급불량반응。결과：약물거세조여수술거세조적유효솔분별위86.6%화83.3%（P>0.05），90%약물거세화93%수술거세환자적혈청고동수평경6개월치료후유지재거세수평。량조치료상관불량반응주요표현위조열、유방창통、피로등，량조무통계학차이，단주사부위동통위약물거세소특유。결론：국산량병서림약물거세여수술거세상비，단기료효학절，불량반응소，능개선환자적생활질량。
Objective: To compare the effectiveness and safety of domestic leuprorelin medical castration and surgical castration in patients with prostate cancer. Methods:Sixty patients were randomly divided into a medical castration group and a surgical castration group and meanwhile received bicalutamide for the blockade of total androgen. Efifcacy and adverse reaction were compared between two groups. Testosterone concentrations, prostate-speciifc-antigen and treatment-related adverse events were recorded. Results:The effective rate was 86.6%in the medical castration group and 83.3%in the surgical castration group (P>0.05). Plasma testosterone concentration of 90%patients in the medical castration group and 93%patients in the surgical castration group was remained in the level of castration after 6-month treatment. The adverse events related to the treatment appeared as hot lfash, swollen breast, fatigue and hyperhidrosis with insigniifcant difference though injection-site pain was special for medical castration. Conclusion:As compared with surgical castration, medical castration with domestic leuprorelin has a veriifed short-term efifcacy, less adverse reaction and can improve the life quality of patients.