CAJ | 학술논문

目的：探讨孕妇血清叶酸状况与胎儿神经管畸形及妊娠结局的关系。方法选取2008-01-2013-06就诊的孕龄26～40周的孕妇5284例，其中不良妊娠结局组孕妇792例，正常妊娠结局组孕妇4492例；筛选出神经管畸形患儿母亲96例作为神经管畸形组，对照组为同期内于我院检查的正常孕妇120例。对比神经管是否畸形及妊娠结局情况与孕妇血清的叶酸水平。结果年龄、孕次、孕周半胱氨酸比较差异无统计学意义（ P＞0.05）；而神经管畸形组叶酸水平明显低于对照组；不良妊娠结局孕妇叶酸水平明显低于正常妊娠结局孕妇，差异有统计学意义（ P＜0.05）。结论较低的血清叶酸水平可能会增加神经管畸形和不良妊娠结局的风险。
목적：탐토잉부혈청협산상황여태인신경관기형급임신결국적관계。방법선취2008-01-2013-06취진적잉령26～40주적잉부5284례，기중불량임신결국조잉부792례，정상임신결국조잉부4492례；사선출신경관기형환인모친96례작위신경관기형조，대조조위동기내우아원검사적정상잉부120례。대비신경관시부기형급임신결국정황여잉부혈청적협산수평。결과년령、잉차、잉주반광안산비교차이무통계학의의（ P＞0.05）；이신경관기형조협산수평명현저우대조조；불량임신결국잉부협산수평명현저우정상임신결국잉부，차이유통계학의의（ P＜0.05）。결론교저적혈청협산수평가능회증가신경관기형화불량임신결국적풍험。
Objective To explore the relationship between the serum folic acid level and neural tube defects and pregnancy outcomes in pregnant women .Methods 5 284 cases of pregnant women from January 2008 to June 2013 were examined at 26-40 weeks of gestational age ,and among them ,792 cases of pregnant women with adverse pregnancy outcomes and 4 492 cases of pregnant women with normal pregnancy outcomes .And 96 cases of foetuses with neural tube defects were screened as neural tube defects group while 120 normal pregnant women during the same period in our hospital were selected as the control group . The relationship between neural tube defects and maternal serum folic acid levels ,pregnancy outcome were compared .Results <br> There were no significant differences in age ,gravidity number ,gestational weeks and cysteine levels (P>0 .05) .The folic acid level of NTDs group was significantly lower than that of the control group ;the level of folic acid of adverse pregnancy out-comes of pregnant women was significantly lower than that in normal pregnancy outcomes of pregnant women ,and the differ-ence was statistically significant (P<0.05).Conclusion The lower level of serum folic acid may increase the risk of neural tube defects and adverse pregnancy outcomes.