中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
25期
4-5
,共2页
杭海燕%刘福生%李培彩%张寅%陈亮%刘婷%苏泽琦%朱辰辰%王晓迪%王龙华%丁霞
杭海燕%劉福生%李培綵%張寅%陳亮%劉婷%囌澤琦%硃辰辰%王曉迪%王龍華%丁霞
항해연%류복생%리배채%장인%진량%류정%소택기%주신신%왕효적%왕룡화%정하
慢性萎缩性胃炎%胃络瘀阻证%环氧化酶-2%胃黏膜病理
慢性萎縮性胃炎%胃絡瘀阻證%環氧化酶-2%胃黏膜病理
만성위축성위염%위락어조증%배양화매-2%위점막병리
Chronic atrophic gastritis%Blood Stagnation in Gastric%Cyclooxygenase-2%Gastric pathology
目的：探讨慢性萎缩性胃炎（CAG）胃络瘀阻证与血清环氧化酶-2（Cox-2）及胃黏膜病变程度的相关性。方法选择经电子胃镜、病理检查确诊为CAG患者，根据中医证型分为胃络瘀阻证和脾胃虚寒证的患者各30例，采用酶联免疫吸附实验（ELISA）的方法检测患者血清Cox-2的表达水平，分析CAG患者胃络瘀阻证与Cox-2及胃黏膜病变程度的相关性。结果 CAG胃络瘀阻证患者血清Cox-2表达水平高于脾胃虚寒证患者，差异有统计学意义（P＜0.05）；CAG胃络瘀阻证患者的胃黏膜病变程度比脾胃虚寒证患者的病变程度较重，差异有统计学意义（P＜0.05）。结论 CAG患者胃络瘀阻证与Cox-2表达水平及胃黏膜病变程度之间具有一定的相关性，为中医药活血化瘀治疗CAG提供了依据。
目的：探討慢性萎縮性胃炎（CAG）胃絡瘀阻證與血清環氧化酶-2（Cox-2）及胃黏膜病變程度的相關性。方法選擇經電子胃鏡、病理檢查確診為CAG患者，根據中醫證型分為胃絡瘀阻證和脾胃虛寒證的患者各30例，採用酶聯免疫吸附實驗（ELISA）的方法檢測患者血清Cox-2的錶達水平，分析CAG患者胃絡瘀阻證與Cox-2及胃黏膜病變程度的相關性。結果 CAG胃絡瘀阻證患者血清Cox-2錶達水平高于脾胃虛寒證患者，差異有統計學意義（P＜0.05）；CAG胃絡瘀阻證患者的胃黏膜病變程度比脾胃虛寒證患者的病變程度較重，差異有統計學意義（P＜0.05）。結論 CAG患者胃絡瘀阻證與Cox-2錶達水平及胃黏膜病變程度之間具有一定的相關性，為中醫藥活血化瘀治療CAG提供瞭依據。
목적：탐토만성위축성위염（CAG）위락어조증여혈청배양화매-2（Cox-2）급위점막병변정도적상관성。방법선택경전자위경、병리검사학진위CAG환자，근거중의증형분위위락어조증화비위허한증적환자각30례，채용매련면역흡부실험（ELISA）적방법검측환자혈청Cox-2적표체수평，분석CAG환자위락어조증여Cox-2급위점막병변정도적상관성。결과 CAG위락어조증환자혈청Cox-2표체수평고우비위허한증환자，차이유통계학의의（P＜0.05）；CAG위락어조증환자적위점막병변정도비비위허한증환자적병변정도교중，차이유통계학의의（P＜0.05）。결론 CAG환자위락어조증여Cox-2표체수평급위점막병변정도지간구유일정적상관성，위중의약활혈화어치료CAG제공료의거。
Objective To discuss the relationship between Blood Stagnation in Gastric and cyclooxygenase-2(Cox-2) as well as pathology in chronic atrophic gastritis(CAG).Method 60 CAG patients made definitely diagnosis by electronic gastroscopy and pathological examination were divided into two groups. One group is 30 patients of Blood Stagnation in Gastric, and the other group is 30 patients of deficiency in the spleen and stomach with cold manifestations. The serum Cox-2 of patients was detected by enzyme-linked immunosorbent assay(ELISA). Then analysis the serum Cox-2 as well as pathology differences between the two groups.Results Compared with the spleen and stomach with cold manifestations group, the serum Cox-2 is higher and the gastric pathology grade is more serious in Blood Stagnation in Gastric group(P<0.05).Conclusion There are some relationships between Blood Stagnation in Gastric and Cox-2 as well as pathology in chronic atrophic gastritis,which may provide a certain basis for treatment of CAG by activating blood circulation.
