中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
26期
101-103,104
,共4页
卡马西平%癫痫%血药浓度监测%液质联用
卡馬西平%癲癇%血藥濃度鑑測%液質聯用
잡마서평%전간%혈약농도감측%액질련용
Cabamazepine%Epilepsy%Plasma concentration determination%LC-MS
目的：建立液谱质谱联用法（LC-MS），对卡马西平（CBZ）进行血药浓度监测，同时探究卡马西平血药浓度与癫痫疗效的关系。方法：以本院小儿神经内科的168例癫痫患者作为研究对象，采用高效液相色谱质谱（liquid chromatography-mass spectrometry，LC-MS）方法对其血药浓度进行监测。结果：卡马西平血药浓度在2.0~40.0 mg/L的范围内线性关系良好（r=0.9967）。168例癫痫患者中有104例的CBZ血药浓度为4~12 mg/L，其中81例显效或有效，23例效果不明显，有效率为77.9%。48例患者的CBZ血药浓度<4 mg/L，占全部患者的28.6%，其中15例患者有效，其余无效；16例患者的CBZ血药浓度>12 mg/L，全部有效。结论：本文中LC-MS方法专属性强，灵敏度、准确度以及重现性均较好，易于操作，可用于癫痫患者血清中卡马西平血药浓度的监测。卡马西平治疗癫痫的疗效以及不良反应和CBZ血药浓度密切相关。
目的：建立液譜質譜聯用法（LC-MS），對卡馬西平（CBZ）進行血藥濃度鑑測，同時探究卡馬西平血藥濃度與癲癇療效的關繫。方法：以本院小兒神經內科的168例癲癇患者作為研究對象，採用高效液相色譜質譜（liquid chromatography-mass spectrometry，LC-MS）方法對其血藥濃度進行鑑測。結果：卡馬西平血藥濃度在2.0~40.0 mg/L的範圍內線性關繫良好（r=0.9967）。168例癲癇患者中有104例的CBZ血藥濃度為4~12 mg/L，其中81例顯效或有效，23例效果不明顯，有效率為77.9%。48例患者的CBZ血藥濃度<4 mg/L，佔全部患者的28.6%，其中15例患者有效，其餘無效；16例患者的CBZ血藥濃度>12 mg/L，全部有效。結論：本文中LC-MS方法專屬性彊，靈敏度、準確度以及重現性均較好，易于操作，可用于癲癇患者血清中卡馬西平血藥濃度的鑑測。卡馬西平治療癲癇的療效以及不良反應和CBZ血藥濃度密切相關。
목적：건립액보질보련용법（LC-MS），대잡마서평（CBZ）진행혈약농도감측，동시탐구잡마서평혈약농도여전간료효적관계。방법：이본원소인신경내과적168례전간환자작위연구대상，채용고효액상색보질보（liquid chromatography-mass spectrometry，LC-MS）방법대기혈약농도진행감측。결과：잡마서평혈약농도재2.0~40.0 mg/L적범위내선성관계량호（r=0.9967）。168례전간환자중유104례적CBZ혈약농도위4~12 mg/L，기중81례현효혹유효，23례효과불명현，유효솔위77.9%。48례환자적CBZ혈약농도<4 mg/L，점전부환자적28.6%，기중15례환자유효，기여무효；16례환자적CBZ혈약농도>12 mg/L，전부유효。결론：본문중LC-MS방법전속성강，령민도、준학도이급중현성균교호，역우조작，가용우전간환자혈청중잡마서평혈약농도적감측。잡마서평치료전간적료효이급불량반응화CBZ혈약농도밀절상관。
Objective:To develop the method of LC-MS for the concentration of Cabamazepine(CBZ)in human blood,and to discuss the relationship between CBZ blood concentration and antiepileptic effects. Method:168 cases epileptic patients in our hospital were retrospectively analyzed.And liquid chromatography-mass spectrometry(LC-MS) has been developed to monitor the CBZ blood concentration. Result:The liner calibration curve of Cabamazepine was obtained in the concentration range of 2.0-40.0 mg/L(r=0.9967). 104 cases CBZ blood concentration was in 4-12 mg/L, 81 cases in their were shown effective and 23 cases were ineffective,the effective ratio was 77.9%. 48 cases CBZ blood concentration was lower than 4 mg/L. 16 cases CBZ blood concentration was higher than 12 mg/L and all these patients were effective. Conclusion:LC-MS method in this article is proper,sensitivity, accuracy and repeatability. Meanwhile it is easy to operate for monitoring the CBZ blood concentration of epileptic patients. The effectively of CBZ and adverse effects are closely related to CBZ blood concentration.
