中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
26期
3-6
,共4页
急性心肌梗死%脑钠肽%早期诊断
急性心肌梗死%腦鈉肽%早期診斷
급성심기경사%뇌납태%조기진단
Acute myocardial infarction%Brain natriuretic peptide%Early diagnosis
目的：探讨血浆BNP在急性心肌梗死患者发病后的动态变化及其对AMI的早期诊断价值。方法：选择稳定型心绞痛（SA）患者22例、不稳定型心绞痛（UA）患者24例及健康对照组20例测定血浆BNP浓度，急性心肌梗死（AMI）患者41例于症状发作后2、4、6、24 h测定血浆BNP浓度。结果：UA组及AMI各时间点BNP水平均明显高于SA组（P<0.01）；且随着症状发作时间的延长而明显增高（P<0.01）。AMI患者症状发作4、6 h ROC曲线下面积分别为0.819和0.898。结论：AMI患者发病2 h血浆BNP就开始增高，且增高的水平与发病时间长短明显相关；血浆BNP用于早期诊断急性心肌梗死有非常好的诊断功能。
目的：探討血漿BNP在急性心肌梗死患者髮病後的動態變化及其對AMI的早期診斷價值。方法：選擇穩定型心絞痛（SA）患者22例、不穩定型心絞痛（UA）患者24例及健康對照組20例測定血漿BNP濃度，急性心肌梗死（AMI）患者41例于癥狀髮作後2、4、6、24 h測定血漿BNP濃度。結果：UA組及AMI各時間點BNP水平均明顯高于SA組（P<0.01）；且隨著癥狀髮作時間的延長而明顯增高（P<0.01）。AMI患者癥狀髮作4、6 h ROC麯線下麵積分彆為0.819和0.898。結論：AMI患者髮病2 h血漿BNP就開始增高，且增高的水平與髮病時間長短明顯相關；血漿BNP用于早期診斷急性心肌梗死有非常好的診斷功能。
목적：탐토혈장BNP재급성심기경사환자발병후적동태변화급기대AMI적조기진단개치。방법：선택은정형심교통（SA）환자22례、불은정형심교통（UA）환자24례급건강대조조20례측정혈장BNP농도，급성심기경사（AMI）환자41례우증상발작후2、4、6、24 h측정혈장BNP농도。결과：UA조급AMI각시간점BNP수평균명현고우SA조（P<0.01）；차수착증상발작시간적연장이명현증고（P<0.01）。AMI환자증상발작4、6 h ROC곡선하면적분별위0.819화0.898。결론：AMI환자발병2 h혈장BNP취개시증고，차증고적수평여발병시간장단명현상관；혈장BNP용우조기진단급성심기경사유비상호적진단공능。
Objective:To discuss the dynamic changes of BNP in the patients of AMI and the clinical significance of the early diagnosis of AMI. Method:Plasma BNP in 22 SA cases,24 UA cases,20 healthy cases were tested and the plasma BNP of 41 AMI cases also were tested in 2,4,6 and 24 h after the onset of AMI.Result:BNP level of AMI group and UA group were obviously higher than that of SA group(P<0.01).Plasma BNP level in 4,6,24 h after onset of AMI were obviously higher than that of UA group(P<0.01).4 h and 6 h after AMI onset the surface area under ROC curve were 0.819 and 0.898. Conclusion:AMI patients have an increased plasma BNP level obviously 2 hours after the onset of AMI,and the BNP level increases significantly with the extension of tine. 4 h and 6 h after the onset of AMI the plasma BNP level have good diagnostic value for AMI.
