CAJ | 학술논문

目的：评价磷酸化胰岛素样生长因子结合蛋白-1（iGfBP-1）预测早产的应用价值。方法选取我院先兆早产孕妇82例作为检测标本组，正常近孕周或足月待产孕妇45例作为对照组，运用免疫层析法检测宫颈分泌物中的iGfBP-1。结果先兆早产组iGfBP-1阳性率48.78%，对照组iGfBP-1阳性率6.67%，两组差异有显著性（P<0.05）；先兆早产组中iGfBP-1阳性40例，一周内分娩率50.12%，阴性42例，一周内分娩率8.50%，两者比较有统计学差异（P<0.05）；对照组中iGfBP-1阳性3例，一周内分娩率66.67%，阴性42例，一周内分娩率4.76%，两者比较有统计学差异（P<0.05）。结论检测宫颈分泌物中iGfBP-1可作为预测早产的检测指标，方法简单易行，有推广价值。
목적：평개린산화이도소양생장인자결합단백-1（iGfBP-1）예측조산적응용개치。방법선취아원선조조산잉부82례작위검측표본조，정상근잉주혹족월대산잉부45례작위대조조，운용면역층석법검측궁경분비물중적iGfBP-1。결과선조조산조iGfBP-1양성솔48.78%，대조조iGfBP-1양성솔6.67%，량조차이유현저성（P<0.05）；선조조산조중iGfBP-1양성40례，일주내분면솔50.12%，음성42례，일주내분면솔8.50%，량자비교유통계학차이（P<0.05）；대조조중iGfBP-1양성3례，일주내분면솔66.67%，음성42례，일주내분면솔4.76%，량자비교유통계학차이（P<0.05）。결론검측궁경분비물중iGfBP-1가작위예측조산적검측지표，방법간단역행，유추엄개치。
Objective to study the value of phosphorylated insulin like growth factor binding protein-1(iGfBP-1)in the prediction of premature labor.Methods 82 pregnant women with threatened premature labor were selected as research subjects, while 45 normal pregnant women as controls. iGfBP-1 in cervical secretion was measured by immunochromatography. Results In those with threatened premature labor, the positive rate of IGFBP-1 was 48.78%, signiifcantly higher than that of the controls(p<0.05). there were 40 cases with iGfBP-1 positive in the study group and the occurrence rate of childbirth within 1 week was 50.12%, which was signiifcantly higher than that of the negative ones(8.50%)(p<0.05). However, there were 3 cases with positive iGfBP-1 in the control group with an occurrence rate of childbirth within 1 week 54.62%, which was higher than that of the negative ones(5.41%)(p<0.05).Conclusion iGfBP-1 can be used in the prediction of premature labor.