CAJ | 학술논문

目的：通过检测热休克蛋白90（HSP90）基因在妊娠期高血压疾病（HDCP）患者血清中的表达，了解其在HDCP病理生理机制中的作用。方法用酶联免疫吸附法检测HSP90在正常妊娠组、HDCP组、轻度子痫前期组、重度子痫前期组静脉血及脐血中的表达。结果 HSP90在HDCP组、轻度子痫前期组、重度子痫前期组外周血和脐血中的表达明显强于正常妊娠组，差异均有统计学意义（P均<0.0l）。结论 HSP90的升高可能与HDCP的发生和发展有非常密切的关系，监测血清中HSP90可为以HSP90为靶点治疗HDCP奠定初步的理论基础。
목적：통과검측열휴극단백90（HSP90）기인재임신기고혈압질병（HDCP）환자혈청중적표체，료해기재HDCP병리생리궤제중적작용。방법용매련면역흡부법검측HSP90재정상임신조、HDCP조、경도자간전기조、중도자간전기조정맥혈급제혈중적표체。결과 HSP90재HDCP조、경도자간전기조、중도자간전기조외주혈화제혈중적표체명현강우정상임신조，차이균유통계학의의（P균<0.0l）。결론 HSP90적승고가능여HDCP적발생화발전유비상밀절적관계，감측혈청중HSP90가위이HSP90위파점치료HDCP전정초보적이론기출。
Objective ThrouGh the detection of heat shock protein 90(HSP90)Gene expression in the peripheral blood in in patients with hypertensive disorders complicatinG preGnancy( HDCP ),to understand its role in the pathophysioloGy of HDCP. Methods The expression of HSP90 was observed in Groups of normal preGnant women,Gestational hypertension patients,mild preeclampsia patients,severe preeclampsia patients by ELISA. Results The expression of HSP90 in peripheral blood of Gestational hypertension Group,mild preeclampsia Group,severe preeclampsia Group were siGnificantly hiGher than normal preGnant Group( P<0. 0l ) . Conclusion HSP90 may have close relationship with the onset and development of HDCP. It can predict HDCP by detectinG the level of HSP90 in peripheral blood.