CAJ | 학술논문

目的：系统评价低分子肝素对重症急性胰腺炎的疗效。方法计算机检索结合手工筛选，选择符合纳入标准的随机或临床对照试验（ CRT、CTT）文献，对所得数据进行Meta分析。结果共纳入6项随机对照研究，重症急性胰腺炎患者共626例，低分子肝素组3l2例，对照组3l4例，低分子肝素组与对照组比较，病死率、治愈率、并发症发生率、中转手术率、平均住院时间差异均有统计学意义（P均<0.05），在凝血功能检验指标凝血酶原时间这一项差异无统计学意义。结论加用低分子肝素治疗重症急性胰腺炎患者总有效率高于对照组，且对患者凝血功能无明显影响，临床应用相对安全。
목적：계통평개저분자간소대중증급성이선염적료효。방법계산궤검색결합수공사선，선택부합납입표준적수궤혹림상대조시험（ CRT、CTT）문헌，대소득수거진행Meta분석。결과공납입6항수궤대조연구，중증급성이선염환자공626례，저분자간소조3l2례，대조조3l4례，저분자간소조여대조조비교，병사솔、치유솔、병발증발생솔、중전수술솔、평균주원시간차이균유통계학의의（P균<0.05），재응혈공능검험지표응혈매원시간저일항차이무통계학의의。결론가용저분자간소치료중증급성이선염환자총유효솔고우대조조，차대환자응혈공능무명현영향，림상응용상대안전。
Objective To elevate the efficacy and safety of low molecular weiGht heparins on severe acute pancreatitis. Methods Random or controlled clinical trials literatures( CRT,CTT ) which met the inclusion criteria were collected by computer retrieval combined with manual screeninG,and the data were analyzed by Meta-analysis. Results There were 6 randomized controlled study,includinG 626 cases severe acute pancreatitis which divided into low molecular weiGht heparin Group(n=3l2)and control Group(n=3l4). There were statistical siGnificant differences between Groups in terms of the mortality rate cure rate,complication rate, operation rate,averaGe hospitalization time( P<0. 05). while the parameters of coaGulation showed no siGnificant difference between two Groups. Conclusion Conventional treatment of SAP with LMWH is superior to conventional therapy in improvinG patients'outcome and decreasinG the mortality. Initial subcutaneous therapy with the LMWH appeared to be effective and safe,which cannot lead to bleedinG tendency.