CAJ | 학술논문

目的：了解我院20l2年临床感染病原菌的分布情况及常见细菌的耐药现状。方法收集20l2年我院临床各科送检标本，采用法国生物梅里埃有限公司VITEK 2 COMPACT全自动微生物鉴定仪进行细菌鉴定及抗菌药物敏感性试验，以WHONET 5.4软件进行数据处理分析。结果共分离出病原菌3456株，其中革兰阳性菌占20.3%，革兰阴性菌占76.8%，真菌占2.9%。葡萄球菌中，耐甲氧西林金黄色葡萄球菌（ MRSA）检出率为44.4%，耐甲氧西林凝固酶阴性葡萄球菌（ MRCNS）检出率为85.5%，未检出万古霉素、利奈唑胺耐药。66.4%的大肠埃希菌产生耐超广谱β-内酰胺酶（ ESBLs），肺炎克雷伯菌则有30.6%产生ESBLs。大肠埃希菌及肺炎克雷伯菌对亚胺培南仍高度敏感。铜绿假单胞菌及鲍曼不动杆菌对亚胺培南耐药率分别为8.3%和58.4%。结论我院临床感染病原体仍以革兰阴性杆菌为主，细菌耐药现象较严重，应加强耐药菌监测，有助于临床合理使用抗菌药物。
목적：료해아원20l2년림상감염병원균적분포정황급상견세균적내약현상。방법수집20l2년아원림상각과송검표본，채용법국생물매리애유한공사VITEK 2 COMPACT전자동미생물감정의진행세균감정급항균약물민감성시험，이WHONET 5.4연건진행수거처리분석。결과공분리출병원균3456주，기중혁란양성균점20.3%，혁란음성균점76.8%，진균점2.9%。포도구균중，내갑양서림금황색포도구균（ MRSA）검출솔위44.4%，내갑양서림응고매음성포도구균（ MRCNS）검출솔위85.5%，미검출만고매소、리내서알내약。66.4%적대장애희균산생내초엄보β-내선알매（ ESBLs），폐염극뢰백균칙유30.6%산생ESBLs。대장애희균급폐염극뢰백균대아알배남잉고도민감。동록가단포균급포만불동간균대아알배남내약솔분별위8.3%화58.4%。결론아원림상감염병원체잉이혁란음성간균위주，세균내약현상교엄중，응가강내약균감측，유조우림상합리사용항균약물。
Objective To investiGate the distribution of clinical infectious pathoGens and druG resistance status of common bacteria in the Ninth Peopleˊs Hospital Affiliated to medicine School of ShanGhai Jiao TonG University in 20l2. Methods Clinical isolated bacterial strains were collected from the Ninth Peopleˊs Hospital Affiliated to medicine School of ShanGhai Jiao TonG University durinG 20l2. The identification of bacteria and antimicrobial susceptibility were determined by VITEK 2 COMPACT automatic microbioloGy analyzer. The data were analyzed by WHONET 5. 4 software. Results A total of 3456 pathoGenic strains were collected. Of them,Gram positive cocci,Gram neGative bacilli and funGus accounted for 20. 3%,76. 8% and 2. 9% respectively. Methicillin resistant strains in S. aureus( MRSA ) and coaGulase neGative Staphylococcus ( MRCNS)accounted for averaGe of 44. 4% and 85. 5% respectively. No vancomycin and linezolid resistant strains were found. Extended spectrumβ-lactamases strains accounted for 66. 4% and 30. 6% in Escherichia coli ( E. coli)and Klebsiella spp respectively. Strains of E. coli and Klebsiella spp were still hiGhly susceptible to imipenem. Resistance rates of P. aeruGinosa and A. baumannii sppstrains to imipenem were 8. 3% and 58. 4%respectively. Conclusion The major clinical pathoGenic microorGanisms in the Ninth Peopleˊs Hospital Affiliated to medicine School of ShanGhai Jiao TonG University are still Gram neGative bacilli. Baterial resistance is serious. It is important to strenGthen the detection of resistant bacteria in routine work,which is useful for rational use of antimicrobial aGents.