中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
37期
6059-6063
,共5页
干细胞%移植%脊髓损伤%神经干细胞%骨髓间充质干细胞%胚胎干细胞%脐带间充质干细胞%脐血间充质干细胞
榦細胞%移植%脊髓損傷%神經榦細胞%骨髓間充質榦細胞%胚胎榦細胞%臍帶間充質榦細胞%臍血間充質榦細胞
간세포%이식%척수손상%신경간세포%골수간충질간세포%배태간세포%제대간충질간세포%제혈간충질간세포
stem cells%spinal cord injuries%stem celltransplantation%mesenchymal stem cells%embryonic stem cells%neural stem cells
背景：目前，脊髓损伤的治疗仍然是世界性难题，采用干细胞移植的方法治疗脊髓损伤是近年来脊髓损伤修复研究的热点之一。目的：综述干细胞移植治疗脊髓损伤基础与临床的研究进展及应用前景。方法：应用计算机检索索PubMed数据库及CNKI数据库2000年以后收录文章，检索词为“脊髓损伤，干细胞，细胞移植”，“spinal cord injury，stem cel ，cel therapy”，筛选干细胞移植治疗脊髓损伤基础与临床研究，排除Meta分析等二次性文献，排除重复或较陈旧的文献，纳入52条篇归纳总结。结果与结论：文章对干细胞种类及生物学特性、干细胞移植治疗脊髓损伤的基本机制、干细胞移植技术、干细胞治疗的疗效等进行了总结，并提出干细胞移植治疗脊髓损伤所面临的问题及展望。
揹景：目前，脊髓損傷的治療仍然是世界性難題，採用榦細胞移植的方法治療脊髓損傷是近年來脊髓損傷脩複研究的熱點之一。目的：綜述榦細胞移植治療脊髓損傷基礎與臨床的研究進展及應用前景。方法：應用計算機檢索索PubMed數據庫及CNKI數據庫2000年以後收錄文章，檢索詞為“脊髓損傷，榦細胞，細胞移植”，“spinal cord injury，stem cel ，cel therapy”，篩選榦細胞移植治療脊髓損傷基礎與臨床研究，排除Meta分析等二次性文獻，排除重複或較陳舊的文獻，納入52條篇歸納總結。結果與結論：文章對榦細胞種類及生物學特性、榦細胞移植治療脊髓損傷的基本機製、榦細胞移植技術、榦細胞治療的療效等進行瞭總結，併提齣榦細胞移植治療脊髓損傷所麵臨的問題及展望。
배경：목전，척수손상적치료잉연시세계성난제，채용간세포이식적방법치료척수손상시근년래척수손상수복연구적열점지일。목적：종술간세포이식치료척수손상기출여림상적연구진전급응용전경。방법：응용계산궤검색색PubMed수거고급CNKI수거고2000년이후수록문장，검색사위“척수손상，간세포，세포이식”，“spinal cord injury，stem cel ，cel therapy”，사선간세포이식치료척수손상기출여림상연구，배제Meta분석등이차성문헌，배제중복혹교진구적문헌，납입52조편귀납총결。결과여결론：문장대간세포충류급생물학특성、간세포이식치료척수손상적기본궤제、간세포이식기술、간세포치료적료효등진행료총결，병제출간세포이식치료척수손상소면림적문제급전망。
BACKGROUND:At present, spinal cord injury treatment is stil the worldwide difficult problem. Using the method of stem cells transplantation to treat the spinal cord injury is one of the hotspots of spinal cord injury repair research in recent years. OBJECTIVE:To summarize the progress and application prospects of stem celltransplantation in the treatment of spinal cord injury. METHODS:A computer-based search of PubMed and CNKI was retrieved for relevant articles concerning stem celltransplantation for treatment of spinal cord injury published after 2000. The keywords were“spinal cord injury, stem cell, celltherapy”in English and Chinese, respectively. Meta-analysis and secondary literature were excluded as wel as repetitive or old literature. Final y, 52 articles were included in result analysis. RESULTS AND CONCLUSION:This article summarizes types and biological characteristics of stem cells, basic mechanism, techniques and therapeutic efficacy of stem celltransplantation in the treatment of spinal cord injury, and proposes the issues and prospects concerning the stem cells transplantation for treatment of spinal cord injury.
