CAJ | 학술논문

背景：骨髓间充质干细胞是骨髓中非造血干细胞的另一类重要干细胞，它可以促进血管再生，而神经迁徙蛋白Slit经多项研究证实也可促进血管再生。目的：针对骨髓间充质干细胞与Slit2的生物学功能、临床应用及促血管生成作用做一综述。方法：计算机检索中国期刊网全文数据库以及PubMed数据库1980至2014年期间有关骨髓间充质干细胞与Slit2的文章。检索词分别为“骨髓间充质干细胞”或“MSCs ”及神经迁徙蛋白Slit2。初检得到436篇文献，最终纳入文章65篇。结果与结论：骨髓间充质干细胞与Slit2二者在血管再生方面都起着重要作用，但二者促进血管再生是否具有相关性目前还尚有争议。假设骨髓间充质干细胞分泌Slit2，那么骨髓间充质干细胞促进血管再生是否与Slit2相关及Slit2/Robo是通过什么途径来调节骨髓间充质干细胞从而促进血管再生还需要更多的研究。如若相关，骨髓间充质干细胞联合Slit2移植将会为治疗脑梗死等中枢神经损伤提供了新的依据和思路。
배경：골수간충질간세포시골수중비조혈간세포적령일류중요간세포，타가이촉진혈관재생，이신경천사단백Slit경다항연구증실야가촉진혈관재생。목적：침대골수간충질간세포여Slit2적생물학공능、림상응용급촉혈관생성작용주일종술。방법：계산궤검색중국기간망전문수거고이급PubMed수거고1980지2014년기간유관골수간충질간세포여Slit2적문장。검색사분별위“골수간충질간세포”혹“MSCs ”급신경천사단백Slit2。초검득도436편문헌，최종납입문장65편。결과여결론：골수간충질간세포여Slit2이자재혈관재생방면도기착중요작용，단이자촉진혈관재생시부구유상관성목전환상유쟁의。가설골수간충질간세포분비Slit2，나요골수간충질간세포촉진혈관재생시부여Slit2상관급Slit2/Robo시통과십요도경래조절골수간충질간세포종이촉진혈관재생환수요경다적연구。여약상관，골수간충질간세포연합Slit2이식장회위치료뇌경사등중추신경손상제공료신적의거화사로。
BACKGROUND:Bone marrow mesenchyme stem cells are important non-hematopoietic stem cells in the bone marrow, which can stimulate angiogenesis. While, Slit can also stimulate angiogenesis, as many studies have proved. OBJECTIVE:To review the biological functions, clinical application and effects of bone marrow mesenchymal stem cells and Slit2 on promoting angiogenesis. METHODS:A computer-based online research of CNKI and PubMed databases was performed to col ect articles published between 1980 and 2014 with the keywords“MSCs”and“Slit2”in Chinese and English. There were 436 articles after the initial survey. Final y, 65 articles were included according inclusion and exclusion criteria. RESULTS AND CONCLUSION:Both bone marrow mesenchymal stem cells and Slit2 play an important role in promoting angiogenesis, but the relevance of bone marrow mesenchymal stem cells and Slit2 is stil controversial. If assuming that bone marrow mesenchymal stem cells secrete Slit2, more researches should be done to reveal whether bone marrow mesenchymal stem cells promoting angiogenesis is relevant to Slit2 and through which signaling pathway Slit2/Robo functions to adjust bone marrow mesenchymal stem cells thus to promote angiogenesis. If relevant, the transplantation of the Slit2 and bone marrow mesenchymal stem cells wil be a promising treatment of cerebral infarction and other central nervous injuries.