CAJ | 학술논문

目的：观察五杞胶囊对大鼠实验性肝纤维化的保护作用。方法 Wistar大鼠随机分为对照组、模型组、阳性药物组及五杞胶囊2、4、8g生药/kg组。皮下注射CCL4花生油溶液10周建立大鼠实验性肝纤维化模型，五杞胶囊给药4周后观察大鼠肝脏系数，测定血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、胆碱酯酶（CHE）活力及白蛋白（ALB）、球蛋白（GLO）、总蛋白（TP）含量，肝组织超氧化物歧化酶（SOD）活性及丙二醛（MDA）、羟脯氨酸（Hyp）含量。结果五杞胶囊能明显降低大鼠肝脏系数，升高大鼠血清ALB含量及A/G比值，降低血清AST、ALT、CHE活力及GLO 含量，减少肝组织Hyp、MDA含量，升高SOD活性。结论五杞胶囊通过减轻肝细胞脂质过氧化损伤改善肝功能，纠正肝纤维化引起的白蛋白降低。
목적：관찰오기효낭대대서실험성간섬유화적보호작용。방법 Wistar대서수궤분위대조조、모형조、양성약물조급오기효낭2、4、8g생약/kg조。피하주사CCL4화생유용액10주건립대서실험성간섬유화모형，오기효낭급약4주후관찰대서간장계수，측정혈청병안산전안매（ALT）、천동안산전안매（AST）、담감지매（CHE）활력급백단백（ALB）、구단백（GLO）、총단백（TP）함량，간조직초양화물기화매（SOD）활성급병이철（MDA）、간포안산（Hyp）함량。결과오기효낭능명현강저대서간장계수，승고대서혈청ALB함량급A/G비치，강저혈청AST、ALT、CHE활력급GLO 함량，감소간조직Hyp、MDA함량，승고SOD활성。결론오기효낭통과감경간세포지질과양화손상개선간공능，규정간섬유화인기적백단백강저。
Objective:To study the protective effects of WUQI Capsule (WQC) on experimental hepatic fibrosis in rats. Methods : Wistar rats were randomly divided into normal group, model group, malotilate group, and WQC 2.0, 4.0 and 8.0 g/kg groups. The experimental hepatic fibrosis model was established by hypodermic injection CCL4 and arachis oil solution for 10 weeks, The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and Cholinesterase(CHE), and the contents of albumin (ALB), globulin (GLO) and total protein (TP) in serum. The activities of superoxide dismutase (SOD) and the contents of malonaldehyde (MDA) and hydroxyproline (Hyp) in liver were observed. Results:After treated by WQC (in a dosage of 4.0 and 8.0 g/kg) for 4 weeks, the coefficient of liver was significantly decreased,the contents of ALB and A/G ratio in serum were significantly increased, the activities of AST, ALT and CHE, and the contents of GLO in serum were significantly decreased, the activities of SOD in liver were significantly increased, and the contents of MDA and Hyp in liver were significantly decreased. Conclusion : WQC can improve hepatic function, correct low albumin induced by hepatic fibrosis with lightening damage of lipid peroxidation in hepatocyte.