人参研究
人參研究
인삼연구
RENSHEN YANJIU
2014年
3期
5-8
,共4页
江一川%张虹%付雯雯%徐华丽%于晓风%睢大筼
江一川%張虹%付雯雯%徐華麗%于曉風%睢大筼
강일천%장홍%부문문%서화려%우효풍%휴대운
5年生种植人参%食用%下丘脑-垂体-肾上腺轴%成年大鼠
5年生種植人參%食用%下丘腦-垂體-腎上腺軸%成年大鼠
5년생충식인삼%식용%하구뇌-수체-신상선축%성년대서
5-year-old planting ginseng%Edible%Hypothalamic-pituitary-adrenal axis%Adult rats
目的：观察5年生种植人参食用对成年大鼠下丘脑-垂体-肾上腺轴的影响，探讨人参食用对机体内分泌系统功能的调节作用。方法正常成年Wistar大鼠随机分为10组，即：对照组，5年生种植人参原粉小、中、大剂量（0.25、0.5、1.0g生药/kg）组，5年生种植人参水提物小、中、大剂量（0.25、0.5、1.0g生药/kg）组，5年生种植人参醇提物小、中、大剂量（0.25、0.5、1.0g生药/kg）组，每组14只。各组大鼠连续灌胃给药3个月，观察下丘脑-垂体-肾上腺轴变化。结果与对照组比较，人参原粉中、大剂量组和人参醇提物大剂量组均可使正常成年大鼠血浆CRH含量降低（P<0.05），人参原粉大剂量组和人参醇提物中、大剂量组均可使正常成年大鼠血浆ACTH的含量降低（P<0.05），人参原粉、人参水提物和人参醇提物各剂量组对正常成年大鼠血清GH，肾上腺、垂体脏器系数以及体重均无明显影响（P>0.05）。结论人参原粉和人参醇提物对正常成年大鼠下丘脑-垂体-肾上腺轴具有一定的调节作用。
目的：觀察5年生種植人參食用對成年大鼠下丘腦-垂體-腎上腺軸的影響，探討人參食用對機體內分泌繫統功能的調節作用。方法正常成年Wistar大鼠隨機分為10組，即：對照組，5年生種植人參原粉小、中、大劑量（0.25、0.5、1.0g生藥/kg）組，5年生種植人參水提物小、中、大劑量（0.25、0.5、1.0g生藥/kg）組，5年生種植人參醇提物小、中、大劑量（0.25、0.5、1.0g生藥/kg）組，每組14隻。各組大鼠連續灌胃給藥3箇月，觀察下丘腦-垂體-腎上腺軸變化。結果與對照組比較，人參原粉中、大劑量組和人參醇提物大劑量組均可使正常成年大鼠血漿CRH含量降低（P<0.05），人參原粉大劑量組和人參醇提物中、大劑量組均可使正常成年大鼠血漿ACTH的含量降低（P<0.05），人參原粉、人參水提物和人參醇提物各劑量組對正常成年大鼠血清GH，腎上腺、垂體髒器繫數以及體重均無明顯影響（P>0.05）。結論人參原粉和人參醇提物對正常成年大鼠下丘腦-垂體-腎上腺軸具有一定的調節作用。
목적：관찰5년생충식인삼식용대성년대서하구뇌-수체-신상선축적영향，탐토인삼식용대궤체내분비계통공능적조절작용。방법정상성년Wistar대서수궤분위10조，즉：대조조，5년생충식인삼원분소、중、대제량（0.25、0.5、1.0g생약/kg）조，5년생충식인삼수제물소、중、대제량（0.25、0.5、1.0g생약/kg）조，5년생충식인삼순제물소、중、대제량（0.25、0.5、1.0g생약/kg）조，매조14지。각조대서련속관위급약3개월，관찰하구뇌-수체-신상선축변화。결과여대조조비교，인삼원분중、대제량조화인삼순제물대제량조균가사정상성년대서혈장CRH함량강저（P<0.05），인삼원분대제량조화인삼순제물중、대제량조균가사정상성년대서혈장ACTH적함량강저（P<0.05），인삼원분、인삼수제물화인삼순제물각제량조대정상성년대서혈청GH，신상선、수체장기계수이급체중균무명현영향（P>0.05）。결론인삼원분화인삼순제물대정상성년대서하구뇌-수체-신상선축구유일정적조절작용。
Objective To observe the effect of 5-year-old planting ginseng on hypothalamic-pituitary-adrenal axis function in normal adult rats, and to investigate the regulation of body's endocrine function through the edible of ginseng. Methods Normal adult Wistar rats were randomly divided into 10 groups:control group, the low, medium, high-dose groups of original powder of 5-year-old planting ginseng (0.25,0.5 and 1.0g crude drug / kg); the low, medium, high-dose groups of water extract from5-year-old planting ginseng (0.25,0.5 and 1.0g crude drug/kg);the low, medium, high-dose group of ethanol extract from 5-year-old planting ginseng (0.25,0.5 and 1.0g crude drug / kg), fourteen rats for each group. The rats were administered orally three consecutive months, and observed the changes of hypothalamic-pituitary-adrenal axis function. Results Compared with the control group, plasma CRH was lower in medium, high-dose groups of ginseng original powder and high-dose group of ethanol extract from ginseng in normal adult rats (P<0.05). Plasma ACTH was lower in high-dose group of ginseng original powder and medium, high-dose groups of ethanol extract from ginseng in normal adult rats (P<0.05). Each dose group of ginseng original powder, ginseng water extract and ethanol extract from ginseng had no significant effect on serum GH in normal adult rats (P>0.05). Each dose group of ginseng original powder,ginseng water extract and ethanol extract from ginseng had no significant effect on serum GH, weight or the viscera coefficient of adrenal and hypophysis in normal adult rats (P>0.05). Conclusion Original powder and alcohol extract from ginseng have some adjustment effect on hypothalamic-pituitary-adrenal axis function in normal adult rats.
