CAJ | 학술논문

背景：不同种类颅骨修补材料具有不同的理化特性及生物相容性。目的：总结颅骨缺损修补材料的研究及应用进展。方法：应用计算机检索中国学术期刊网络出版总库、万方数据库及PudMed数据库1988至2014年的相关文献，检索关键词为“颅骨修补材料，理化特性，生物相容性，钛合金，自体颅骨”。结果与结论：通过检索文献对颅骨修补材料的临床应用及研究进程分析，对不同时期不同种类颅骨修补材料性能及临床应用的优缺点比较，掌握不同颅骨修补材料的理化特性及生物相容性，总结不同患者选择不同颅骨修补材料及颅骨修补的时机及方法。金属材料钛和钛合金因具有良好的生物相容性及理化特性，临床应用文献观察并发症少，已成为目前临床应用最广泛的颅骨修补材料；而自体颅骨骨瓣因其组织来源一致、无任何排异反应仍应为最为理想的颅骨修补材料。近年来发展的骨组织工程技术，因其可仿制自体颅骨为颅骨缺损的修复提供了新的研究应用方向。
배경：불동충류로골수보재료구유불동적이화특성급생물상용성。목적：총결로골결손수보재료적연구급응용진전。방법：응용계산궤검색중국학술기간망락출판총고、만방수거고급PudMed수거고1988지2014년적상관문헌，검색관건사위“로골수보재료，이화특성，생물상용성，태합금，자체로골”。결과여결론：통과검색문헌대로골수보재료적림상응용급연구진정분석，대불동시기불동충류로골수보재료성능급림상응용적우결점비교，장악불동로골수보재료적이화특성급생물상용성，총결불동환자선택불동로골수보재료급로골수보적시궤급방법。금속재료태화태합금인구유량호적생물상용성급이화특성，림상응용문헌관찰병발증소，이성위목전림상응용최엄범적로골수보재료；이자체로골골판인기조직래원일치、무임하배이반응잉응위최위이상적로골수보재료。근년래발전적골조직공정기술，인기가방제자체로골위로골결손적수복제공료신적연구응용방향。
BACKGROUND:Different kinds of skul repair materials have different physicochemical properties and biocompatibilities. OBJECTIVE:To summarize the research and application progress in skul defect repair materials. METHODS:A computer-based search of China Academic Journal Network Publishing Database, Wanfang and PubMed databases was performed for articles published from 1988 to 2014 with the keywords of“bone repair materials, physical and chemical properties, biocompatibility, titanium al oy, autologous skul”in Chinese and English, respectively. RESULTS AND CONCLUSION:By the literature retrieval, the clinical application and research progress of bone repair materials are analyzed, properties and clinical application of different types of skul repair materials at different periods are compared, to master the physical and chemical properties and biocompatibility of different skul repair materials as wel as to summarize the timing and methods of skul repair in individual patients. Titanium and titanium al oys have been used widely as skul repair materials because of their good biocompatibility, physicochemical properties, and fewer complications. Autologous skul bone flaps have been the ideal materials for skul repair because its origin is consistent, without any rejection. Bone tissue engineering technology developed in recent years provides a new research direction for skul repair, because it can be used to copy autologous skul .