CAJ | 학술논문

背景：金纳米棒具有独特的光学性质、良好的组织相容性、易控的表面修饰性，其在生物及医学领域有着广阔的应用前景。目的：综述金纳米颗粒特别是金纳米棒的光学性质、光热疗法及对肿瘤放射增敏的机制与研究进展。方法：由作者检索 PubMed 数据库和中国知网数据库获得文献，英文检索词为“gold nanoparticles ， radiotherapy sensitivity”，中文检索词为“金纳米颗粒，放疗增敏”。纳入用于体内外临床研究的金纳米颗材料，以及与肿瘤放疗敏感相关的金纳米颗粒研究。结果与结论：金纳米颗粒拥有独特的表面等离子共振效应，与传统球形金纳米颗粒不同的是，金纳米棒具有2个表面等离子共振效应峰，分别对应其横轴和纵轴2个特征尺寸。通过控制不同纵横轴比能够实现纵向表面等离子共振效应峰位置的人为调控，为金纳米棒自由进入近红外光区开辟了一条有效路径。金纳米棒具有低毒、高效、高产而作为一种新颖放射增敏剂，其增敏作用不仅与照射剂量、自身浓度、自身尺寸、表面修饰物有关，尚与放射线的种类和所取得细胞系种类等多种因素相关。但金纳米棒放射增敏作用如何避免放射线种类的限制、如何选择适宜修饰物提高靶向性高效杀伤肿瘤，以及如何最大程度利用金纳米棒等还需进一步优化和深入。
배경：금납미봉구유독특적광학성질、량호적조직상용성、역공적표면수식성，기재생물급의학영역유착엄활적응용전경。목적：종술금납미과립특별시금납미봉적광학성질、광열요법급대종류방사증민적궤제여연구진전。방법：유작자검색 PubMed 수거고화중국지망수거고획득문헌，영문검색사위“gold nanoparticles ， radiotherapy sensitivity”，중문검색사위“금납미과립，방료증민”。납입용우체내외림상연구적금납미과재료，이급여종류방료민감상관적금납미과립연구。결과여결론：금납미과립옹유독특적표면등리자공진효응，여전통구형금납미과립불동적시，금납미봉구유2개표면등리자공진효응봉，분별대응기횡축화종축2개특정척촌。통과공제불동종횡축비능구실현종향표면등리자공진효응봉위치적인위조공，위금납미봉자유진입근홍외광구개벽료일조유효로경。금납미봉구유저독、고효、고산이작위일충신영방사증민제，기증민작용불부여조사제량、자신농도、자신척촌、표면수식물유관，상여방사선적충류화소취득세포계충류등다충인소상관。단금납미봉방사증민작용여하피면방사선충류적한제、여하선택괄의수식물제고파향성고효살상종류，이급여하최대정도이용금납미봉등환수진일보우화화심입。
BACKGROUND:Gold nanorods have unique optical properties, good histocompatibility, easily control ed surface modification, which have a broad application prospect in the field of biology and medicine. OBJECTIVE:To summarize the optical and thermal properties of gold nanoparticles, and to review the mechanism and research advances of gold nanoparticles, especial y gold nanorods in tumor sensitize radiotherapy. METHODS:A computer-based search of PubMed and CNKI databases was undertaken with the keywords of“gold nanoparticles, radiotherapy sensitivity”in English and Chinese, respectively. The included articles were related to nanoparticles used in vitro and in vivo for clinic study as wel as gold nanoparticles-related tumor sensitize radiotherapy. RESULTS AND CONCLUSION:Gold nanoparticles exhibit unique properties of surface plasmon resonance properties. Compared with the traditional spherical gold nanoparticles, gold nanorods are capsule-like gold nanoparticles containing two absorption peaks that are a transverse surface plasmon resonance absorption peak and a longitudinal surface plasmon resonance absorption peak corresponding to the dimensional characteristics of their horizontal axis and vertical axis, respectively. By regulation of the ratio of horizontal axis and vertical axis, we can realize the manipulation of the longitudinal surface plasmon resonance absorption peak location. Thus, the longitudinal surface plasmon resonance absorption peak can be changed from visible region to the near-infrared region which is the most ideal optical transmission through for al of biological tissues. As a kind of novel radiotherapy sensitization agent, gold nanorods have the properties of low toxicity, high efficiency, high yield. Its sensitization effect is not only related to the exposure dose, own concentration and size, surface modified compounds, but also related to the types of radiation and celllines. However, for radiotherapy sensitization of gold nanorods how to avoid the limits of radioactive ray species, choose appropriate trim and maximize the use of gold nanorods stil need a further research.