CAJ | 학술논문

背景：以胶原及丝素蛋白材料为构架的脊髓生物支架，已被证实可以修复或部分修复受损的脊髓神经功能。目的：介绍胶原蛋白和丝素蛋白的部分特性，并对近年来其作为支架材料在脊髓组织工程中的应用及进展作一综述。方法：应用计算机检索CNKI和PubMed数据库中2003年1月至2012年10月关于胶原蛋白及丝素蛋白支架材料在脊髓损伤中应用的文章，在主题和中中文以“胶原蛋白，丝素蛋白，支架材料，脊髓损伤”为检索词检索；英文以“col agen；silk fibroin；spinal cord injury”为检索词进行检索。结果与结论：胶原蛋白具有低抗原性、优良的生物相容性和生物降解性，本身及其降解产物在人体内不会引起炎症反应，但存在降解速度过快及力学性能差等缺点。丝素蛋白具有良好的生物相容性及优良的力学性能，但降解速度较慢。将胶原蛋白和丝素蛋白用静电共纺的方法制备成复合体，可以在保持良好生物相容性的基础上，提高材料的物理性能。目前，国内外已对丝素或胶原蛋白材料在神经系统修复方面的应用做了一些研究，为脊髓组织工程奠定了一些基础；又考虑到胶原和丝素材料与脊髓软组织的特性和力学性能相似，胶原/丝素蛋白复合材料有望成为脊髓组织工程理想的支架材料。
배경：이효원급사소단백재료위구가적척수생물지가，이피증실가이수복혹부분수복수손적척수신경공능。목적：개소효원단백화사소단백적부분특성，병대근년래기작위지가재료재척수조직공정중적응용급진전작일종술。방법：응용계산궤검색CNKI화PubMed수거고중2003년1월지2012년10월관우효원단백급사소단백지가재료재척수손상중응용적문장，재주제화중중문이“효원단백，사소단백，지가재료，척수손상”위검색사검색；영문이“col agen；silk fibroin；spinal cord injury”위검색사진행검색。결과여결론：효원단백구유저항원성、우량적생물상용성화생물강해성，본신급기강해산물재인체내불회인기염증반응，단존재강해속도과쾌급역학성능차등결점。사소단백구유량호적생물상용성급우량적역학성능，단강해속도교만。장효원단백화사소단백용정전공방적방법제비성복합체，가이재보지량호생물상용성적기출상，제고재료적물이성능。목전，국내외이대사소혹효원단백재료재신경계통수복방면적응용주료일사연구，위척수조직공정전정료일사기출；우고필도효원화사소재료여척수연조직적특성화역학성능상사，효원/사소단백복합재료유망성위척수조직공정이상적지가재료。
BACKGROUND:Col agen and silk fibroin materials for construction of spinal cord scaffolds have been proven to repair or partial y repair damaged spinal cord nerve function. OBJECTIVE:To introduce partial characteristics of the col agen and silk fibroin and to review the recent progress and application as scaffolds in spinal cord tissue engineering. METHODS:A computer-based search of CNKI and PubMed databases (2003-01/2012-10) was performed for articles addressing the application of col agen and silk fibroin scaffolds in spinal cord injury with the keywords of“col agen, silk fibroin, scaffold, spinal cord injury”in Chinese and English, respectively. RESULTS AND CONCLUSION:Col agen has low antigenicity, good biocompatibility and biodegradability. Col agen and its degradation products can cause no inflammatory reactions in the body, but have the disadvantages of rapid degradation and poor mechanical properties. Silk fibroin has good biocompatibility and excellent mechanical properties, but its degradation is slow. The col agen and silk fibroin are compounded using an electrostatic spinning technology to improve the physical properties of the material on the basis of maintaining good biocompatibility. At present, fibroin or col agen materials in terms of nervous system repair have been studied, laying some foundation for spinal cord tissue engineering. Considering the similar characteristics and mechanics performance to the spinal cord tissue, col agen/silk fibroin composite materials are expected to become the ideal scaffold materials for spinal cord tissue engineering.