CAJ | 학술논문

近年来肿瘤相关巨噬细胞( tumor-associated macrophages, TAMs)与肿瘤的关系成为研究热点,尤其是肝癌等实体肿瘤。肿瘤微环境中的TAMs释放多种细胞因子和趋化因子介导免疫反应,通过参与上皮细胞间质转化( epithelial-mesenchymaltransitions, EMT),血管生成等过程促进肝癌的侵袭和转移。本文将从TAMs的募集和分化、与肿瘤微环境的关系、促进转移的机制、与肝癌之间的通路以及靶向TAMs治疗肝癌的新方法等方面对TAMs在肝癌中的研究进展进行综述。
근년래종류상관거서세포( tumor-associated macrophages, TAMs)여종류적관계성위연구열점,우기시간암등실체종류。종류미배경중적TAMs석방다충세포인자화추화인자개도면역반응,통과삼여상피세포간질전화( epithelial-mesenchymaltransitions, EMT),혈관생성등과정촉진간암적침습화전이。본문장종TAMs적모집화분화、여종류미배경적관계、촉진전이적궤제、여간암지간적통로이급파향TAMs치료간암적신방법등방면대TAMs재간암중적연구진전진행종술。
The relationships between the tumor-associated macrophage and tumor become a research hotspot in re-cent years, especially hepatocellular carcinoma and other solid tumors. TAMs release multiple cytokines and chemokines mediated immune responses in the tumor microenvironment, they promote the local invasion and distant metastasis by par-ticipating in the epithelial mesenchymal transitions and angiogenesis. This article will discuss TAMs in following aspects:re-cruiment and differentiation,the roles in tumor microenvironment, mechanisms to promote invasion and and metastasis,the pathways linked to HCC and the new treatments targeted TAMs.