CAJ | 학술논문

目前认为,雄激素性秃发的发病与雄激素、雄激素受体及雄激素代谢相关酶密切相关.近年来更多关注的是,雄激素通过调节毛乳头细胞分泌的各类细胞因子,目前胰岛素样生长因子-1、血管内皮生长因子、转化生长因子-β和Wnt通路抑制因子-1等是雄激素性秃发发病机制中重要的、也是被研究论证较完善的细胞因子.各细胞因子分别促进或抑制毛囊或毛发的生长,以此实现对毛发生长的调控.
목전인위,웅격소성독발적발병여웅격소、웅격소수체급웅격소대사상관매밀절상관.근년래경다관주적시,웅격소통과조절모유두세포분비적각류세포인자,목전이도소양생장인자-1、혈관내피생장인자、전화생장인자-β화Wnt통로억제인자-1등시웅격소성독발발병궤제중중요적、야시피연구론증교완선적세포인자.각세포인자분별촉진혹억제모낭혹모발적생장,이차실현대모발생장적조공.
It is widely accepted that the occurrence of androgenetic alopecia (AGA) is closely related to androgen,androgen receptor and androgen-metabolizing enzymes.However,how they work in AGA remains unclear.Recent studies have shown that androgen exerts their roles by regulating various cytokines secreted by dermal papilla cells.At present,it is considered that insulin-like growth factor,vascular endothelial growth factor,transforming growth factor-β and Wnt inhibitory factor-1 are the most important and well-studied cytokines in the pathogenesis of AA,which may modulate hair growth via accelerating or deccelarating the growth of hair follicles.