国外医学(医学地理分册)
國外醫學(醫學地理分冊)
국외의학(의학지리분책)
FOREIGN MEDICAL SCIENCES(SECTION OF MEDGEOGRAPHY)
2014年
3期
247-251
,共5页
砷%DNA甲基化%DNMT%致癌作用
砷%DNA甲基化%DNMT%緻癌作用
신%DNA갑기화%DNMT%치암작용
arsenic%DNA methylation%DNMT%carcinogenesis
大量研究显示表观遗传变化,尤其是DNA甲基化是砷致癌的关键。砷引起基因甲基化状态改变,能够激活癌基因表达或使抑癌基因沉默,导致控制细胞转化的基因活性长期变化。研究表明体内或体外砷暴露与不同基因位点低甲基化或高甲基化均相关,但存在分歧。本文重点讨论DNA甲基化变化是砷致癌作用的依据。
大量研究顯示錶觀遺傳變化,尤其是DNA甲基化是砷緻癌的關鍵。砷引起基因甲基化狀態改變,能夠激活癌基因錶達或使抑癌基因沉默,導緻控製細胞轉化的基因活性長期變化。研究錶明體內或體外砷暴露與不同基因位點低甲基化或高甲基化均相關,但存在分歧。本文重點討論DNA甲基化變化是砷緻癌作用的依據。
대량연구현시표관유전변화,우기시DNA갑기화시신치암적관건。신인기기인갑기화상태개변,능구격활암기인표체혹사억암기인침묵,도치공제세포전화적기인활성장기변화。연구표명체내혹체외신폭로여불동기인위점저갑기화혹고갑기화균상관,단존재분기。본문중점토론DNA갑기화변화시신치암작용적의거。
A large number of researches have suggested that carcinogenicity results from epigenetic changes, especially DNA methylation.Changes in gene methylation status induced by arsenic have been supposed to activate oncogene expression or silence tumor suppressor genes,leading to long-term changes in the activity of genes control-ling cell transformation.Studies have shown that arsenic exposure is associated with both hypo-and hyper-methyla-tion at various genetic loci in vivo or in vitro,but lots of them are controversial.This paper discussed the evidence supporting changes in DNA methylation as a cause of arsenic carcinogenesis.