组织工程与重建外科杂志
組織工程與重建外科雜誌
조직공정여중건외과잡지
JOURNAL OF TISSUE ENGINEERING AND RECONSTRUCTIVE SURGERY
2014年
4期
232-235
,共4页
王天佑(综述)%林晓曦(审校)
王天祐(綜述)%林曉晞(審校)
왕천우(종술)%림효희(심교)
光动力学疗法%葡萄酒色斑%光敏剂%激发光源
光動力學療法%葡萄酒色斑%光敏劑%激髮光源
광동역학요법%포도주색반%광민제%격발광원
Photodynamic therapy%Port-wine stain%Photo sensitizer%Excitation light source
上世纪90年代，我国首先开始将光动力学疗法（Photodynamic Therapy，PDT）用于葡萄酒色斑（Port Wine Stain，PWS）的治疗。PDT由两大重要因素构成：光敏剂、激发光源。光动力学疗法通过直接杀伤细胞，破坏病灶血管，引发细胞凋亡，免疫调节等来发挥作用。因其对靶组织具有高敏感性，可减少正常组织的损伤。目前，PDT主要用于皮肤外生性疾病和眼、鼻腔、口腔及呼吸道、消化道、泌尿生殖道等腔道内肿瘤的治疗。本文就PDT在治疗葡萄酒色斑上的应用及研究进展进行综述。
上世紀90年代，我國首先開始將光動力學療法（Photodynamic Therapy，PDT）用于葡萄酒色斑（Port Wine Stain，PWS）的治療。PDT由兩大重要因素構成：光敏劑、激髮光源。光動力學療法通過直接殺傷細胞，破壞病竈血管，引髮細胞凋亡，免疫調節等來髮揮作用。因其對靶組織具有高敏感性，可減少正常組織的損傷。目前，PDT主要用于皮膚外生性疾病和眼、鼻腔、口腔及呼吸道、消化道、泌尿生殖道等腔道內腫瘤的治療。本文就PDT在治療葡萄酒色斑上的應用及研究進展進行綜述。
상세기90년대，아국수선개시장광동역학요법（Photodynamic Therapy，PDT）용우포도주색반（Port Wine Stain，PWS）적치료。PDT유량대중요인소구성：광민제、격발광원。광동역학요법통과직접살상세포，파배병조혈관，인발세포조망，면역조절등래발휘작용。인기대파조직구유고민감성，가감소정상조직적손상。목전，PDT주요용우피부외생성질병화안、비강、구강급호흡도、소화도、비뇨생식도등강도내종류적치료。본문취PDT재치료포도주색반상적응용급연구진전진행종술。
Photodynamic therapy (PDT) was firstly applied for treating port-wine stain (PWS) in the 1990s in China. PDT is composed of two major factors, photo sensitizer and excitation light source. PDT can kill cells directly, destroy vessels of le-sions, trigger apoptosis and play a role in immunoregulation by its phototoxic effect. It is currently used for the treatment of skin diseases, tumors in eyes, nose, mouth and respiratory, gastrointestinal, genitourinary tract, and other cavity owing to its high selectivity. In this article, PDT application and its research progress in the treatment of port-wine stain were reviewed.
