CAJ | 학술논문

目的：研究江浙蝮蛇毒镇痛C4组分的中枢镇痛作用并初步探讨其镇痛机理。方法：通过侧脑室给药、脊髓化鼠镇痛实验和足跖定压刺激试验研究C4组分的镇痛作用部位；通过C4组分与阿托品、利血平、纳络酮药物的相互作用，研究其与乙酰胆碱受体、阿片受体间的作用关系。结果：C4组分的镇痛部位主要在脑中枢，且C4组分不通过乙酰胆碱受体作用，而与阿片受体相关。结论：江浙蝮蛇毒C4组分镇痛通过中枢起效，提示江浙蝮蛇毒C4组分可能与增加内源性阿片肽系统的活动有关。
목적：연구강절복사독진통C4조분적중추진통작용병초보탐토기진통궤리。방법：통과측뇌실급약、척수화서진통실험화족척정압자격시험연구C4조분적진통작용부위；통과C4조분여아탁품、리혈평、납락동약물적상호작용，연구기여을선담감수체、아편수체간적작용관계。결과：C4조분적진통부위주요재뇌중추，차C4조분불통과을선담감수체작용，이여아편수체상관。결론：강절복사독C4조분진통통과중추기효，제시강절복사독C4조분가능여증가내원성아편태계통적활동유관。
Objective:To research the central analgesic effect of C 4 protein in snake venom of Agkistrodon halys Pallas and explore the mechanism.Methods:Using the experiments of spinal cord break , lateral ventricle injection and toe press to research the central analgesic action; the relationships of C4 protein with acetycholine receptors, vesicle transmitters and opiate receptors were explored through the interaction of C 4 prtoein with atro-pine, reserpine and naloxon.Results:C4 protein played a role in CNS and the action of C 4 protein was related with opiate receptors instead of acetycholine receptors.Conclusion:Analgesic effect of C 4 protein was acted on central system, which was related with the endogenous opioid peptide system.