中国中医药科技
中國中醫藥科技
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CHINESE JOURNAL OF TRADITIONAL MEDICAL SCIENCE AND TECHNOLOGY
2014年
5期
491-493
,共3页
陈亚男%尚官敏%李海金%葛丽娜%赵建刚%王伟英%李英%董良
陳亞男%尚官敏%李海金%葛麗娜%趙建剛%王偉英%李英%董良
진아남%상관민%리해금%갈려나%조건강%왕위영%리영%동량
气阴两虚证%气虚痰湿证%肺癌晚期%参麦注射液%血管内皮细胞生长因子%碱性成纤维细胞生长因子
氣陰兩虛證%氣虛痰濕證%肺癌晚期%參麥註射液%血管內皮細胞生長因子%堿性成纖維細胞生長因子
기음량허증%기허담습증%폐암만기%삼맥주사액%혈관내피세포생장인자%감성성섬유세포생장인자
qi and yin deficiency syndrome%qi deficiency and phlegm -dampness syndrome%advanced stage lung cancer%Shenmai injection%VEGF bFGF
目的:探讨参麦注射液对不同证型晚期肺癌患者血管内皮细胞生长因子( VEGF)及碱性成纤维细胞生长因子( bFGF)水平的调节作用。方法:将符合纳入标准的51例晚期肺癌患者,辨证分别归于气阴两虚证组及气虚痰湿证组,两组均给予参麦注射液静脉输注,治疗两个疗程。采用双抗夹心酶联免疫吸附法( ELISA)检测治疗前后血清VEGF和bFGF含量。结果:治疗后,两组患者血清bFGF水平均有所下降,差异有显著性;气阴两虚证组的VEGF水平亦有所下降,差异显著;气阴两虚证组的VEGF和bFGF下降较气虚痰湿证组显著;治疗前后两组VEGF和bFGF水平均呈正相关。结论:参麦注射液能有效地抑制气阴两虚证晚期肺癌患者的血清VEGF、bFGF水平,且可能增强气阴两虚证晚期肺癌的VEGF和bFGF的协同作用。
目的:探討參麥註射液對不同證型晚期肺癌患者血管內皮細胞生長因子( VEGF)及堿性成纖維細胞生長因子( bFGF)水平的調節作用。方法:將符閤納入標準的51例晚期肺癌患者,辨證分彆歸于氣陰兩虛證組及氣虛痰濕證組,兩組均給予參麥註射液靜脈輸註,治療兩箇療程。採用雙抗夾心酶聯免疫吸附法( ELISA)檢測治療前後血清VEGF和bFGF含量。結果:治療後,兩組患者血清bFGF水平均有所下降,差異有顯著性;氣陰兩虛證組的VEGF水平亦有所下降,差異顯著;氣陰兩虛證組的VEGF和bFGF下降較氣虛痰濕證組顯著;治療前後兩組VEGF和bFGF水平均呈正相關。結論:參麥註射液能有效地抑製氣陰兩虛證晚期肺癌患者的血清VEGF、bFGF水平,且可能增彊氣陰兩虛證晚期肺癌的VEGF和bFGF的協同作用。
목적:탐토삼맥주사액대불동증형만기폐암환자혈관내피세포생장인자( VEGF)급감성성섬유세포생장인자( bFGF)수평적조절작용。방법:장부합납입표준적51례만기폐암환자,변증분별귀우기음량허증조급기허담습증조,량조균급여삼맥주사액정맥수주,치료량개료정。채용쌍항협심매련면역흡부법( ELISA)검측치료전후혈청VEGF화bFGF함량。결과:치료후,량조환자혈청bFGF수평균유소하강,차이유현저성;기음량허증조적VEGF수평역유소하강,차이현저;기음량허증조적VEGF화bFGF하강교기허담습증조현저;치료전후량조VEGF화bFGF수평균정정상관。결론:삼맥주사액능유효지억제기음량허증만기폐암환자적혈청VEGF、bFGF수평,차가능증강기음량허증만기폐암적VEGF화bFGF적협동작용。
Ob jective:To analyze the regulatory effect of Shenmai injection on VEGF and bFGF levels in ad-vanced stage lung cancer patients with deficiency of qi and yin syndrome or qi deficiency and phlegm -dampness syndrome.Methods:51 Cases advanced stage lung cancer patients who met the inclusive standards of western medication were divided into deficiency of qi and yin syndrome group and qi deficiency and phlegm -dampness syndrome group according to differentiation standards in TCM .Both groups were given Shenmai injection (50mL) into 250mL 5%GS intravenously for 14consecutive days among the 21-day period,both groups repeated 2 treat-ment periods .The contents of VEGF and bFGF were assayed by ELISA in the patients before and after treatment . Results:After the treatment,the level of serum bFGF in both groups was significantly decreased (P<0.001),the level of VEGF in deficiency of qi and yin syndrome group was also significantly decreased ,which had statistical difference to compare with before treatment (P<0.01).The range of decline of VEGF and bFGF in deficiency of qi and yin syndrome group was more apparent (P=0.038,P=0.045).Serum VEGF level was positively correla-ted with serum bFGF level in both groups .Conclusion: Shenmai injection can inhibit serum VEGF and bFGF levels more effectively in advanced stage lung cancer patients , that probably enhance the synergistic effect of VEGF and bFGF in advanced stage lung cancer patients with deficiency of qi and yin syndrome .