CAJ | 학술논문

目的：观察解毒化瘀通络方治疗白塞氏病的临床疗效并探讨其作用机理。方法：将70例白塞氏病患者随机分为两组，治疗组35例予解毒化瘀通络方治疗，对照组35例予雷公藤多苷片治疗；另选30名健康者作为健康组。治疗前后分别测定健康组和两组白塞氏病患者血浆内皮素（ ET ）含量；并观察治疗组和对照组的临床疗效。结果：两个疗程后，治疗组愈显率为74.3％，对照组愈显率为51.4％；4个疗程后治疗组愈显率为80.0％，对照组愈显率为54.3％；两组比较差异有统计学意义（ P＜0.05）。治疗组能显著降低血浆内皮素水平（ P＜0.01）。结论：解毒化瘀通络方治疗白塞氏病有较好的疗效，且能降低ET水平。
목적：관찰해독화어통락방치료백새씨병적림상료효병탐토기작용궤리。방법：장70례백새씨병환자수궤분위량조，치료조35례여해독화어통락방치료，대조조35례여뢰공등다감편치료；령선30명건강자작위건강조。치료전후분별측정건강조화량조백새씨병환자혈장내피소（ ET ）함량；병관찰치료조화대조조적림상료효。결과：량개료정후，치료조유현솔위74.3％，대조조유현솔위51.4％；4개료정후치료조유현솔위80.0％，대조조유현솔위54.3％；량조비교차이유통계학의의（ P＜0.05）。치료조능현저강저혈장내피소수평（ P＜0.01）。결론：해독화어통락방치료백새씨병유교호적료효，차능강저ET수평。
Objective:To study the therapeutic effect of Jiedu huayu tongluo formula on Behcet ’ s disease of progressive stage and its mechanism.Methods:70 patients of Behcet ’ s disease were randomized into treatment group( 35 cases ) which treated by Jiedu huayu tongluo formula , and control group ( 35 cases ) which treated by tripterygium glycosides tablet , 30 healthy subjects were taken as normal control.The conten of plasma endothelin (ET) was determined before and after treatment respectively ,and the curative effect of both treated groups were observed.Results:After two treatment coures ,the markedly effective rate of the treatment group was 74.3%,that in control group was 51.4%;after four treatment coures ,the markedly effective rate of the treatment group was 80%,that in control group was 54.3%,the difference between the two groups was statistical significance ( P<0.05 ).The treatment group can significantly reduce the plasma endothelin content ( P<0.01 ).Conclusion:Jiedu huayu tongluo formula is effective for Behcet ’ s disease of progressive stage and decreasing the content of ET was one of the mechanism.