CAJ | 학술논문

目的：对云南3所特殊教育学校聋生人群进行系统性的耳聋临床资料分析，为开展耳聋基因的分子流行病学研究提供参考依据。方法了解聋生详细的耳聋病史；进行全身及耳鼻咽喉常规检查；进行纯音听阈测试及声导抗测试，了解聋生双耳听功能和中耳功能状况。结果聋生耳聋前有耳毒性药物用药史者占8.2%，有家族史者占19.5%，综合征性耳聋占5.3％，耳聋病因不明者亦占较大比例；汉族与非汉族聋生在综合征性耳聋和聋前用药史方面无显著差异，汉族聋生有家族史的比例高于非汉族聋生。结论云南省聋生可能的致聋原因有遗传性聋、药物性聋，但大部分聋生病因不明，尚需借助分子生物学理论和技术，从基因水平进行耳聋病因学的深入研究。
목적：대운남3소특수교육학교롱생인군진행계통성적이롱림상자료분석，위개전이롱기인적분자류행병학연구제공삼고의거。방법료해롱생상세적이롱병사；진행전신급이비인후상규검사；진행순음은역측시급성도항측시，료해롱생쌍이은공능화중이공능상황。결과롱생이롱전유이독성약물용약사자점8.2%，유가족사자점19.5%，종합정성이롱점5.3％，이롱병인불명자역점교대비례；한족여비한족롱생재종합정성이롱화롱전용약사방면무현저차이，한족롱생유가족사적비례고우비한족롱생。결론운남성롱생가능적치롱원인유유전성롱、약물성롱，단대부분롱생병인불명，상수차조분자생물학이론화기술，종기인수평진행이롱병인학적심입연구。
Objective To analyze the clinical data of the deaf students at three special education schools in Yunnan Province with the purpose of providing more information for the molecular epidemiological study of deafness-related genes. Methods The medical history of the deaf students was taken. All the subjects underwent general physical examination and otolaryngological examinations including pure-tone audiometry and acoustic immittance measurement.Results The epidemiological study found that 8.2% of the deaf students had a history of ototoxic drug use before deafness, 19.5% had a family history of deafness and 5.3% was diagnosed with syndromic hearing loss, but there were still a large proportion of students with deafness of unknown etiology. There was no significant difference in syndromic hearing loss and history of ototoxic drug use before deafness between Han and non-Han students. However, the percentage of students with a family history of deafness among Han students was higher than that among non-Han students.Conclusion The possible etiologies for the deafness of deaf students in Yunnan province include genetic factors and ototoxic drug use, but the causes for most cases of deafness was unknown. Therefore, further genetic and molecular biological studies are still needed.