CAJ | 학술논문

目的：探讨叶酸和维生素 B12与阿尔茨海默病精神障碍( BPSD)的相关性。方法：对77例阿尔茨海默病( AD)患者( BPSD组40例,非BPSD组37例)及39例正常对照组进行叶酸和维生素B12测定,并分析其与BPSD及认知功能障碍的关系。结果： BPSD组和非BPSD组血浆叶酸水平明显低于对照组( P<0．05),而BPSD组与非BPSD组未见明显差异(P>0．05)。 BPSD组和非BPSD组血浆维生素B12水平明显低于对照组(P<0．01),且BPSD组显著低于非BPSD组(P<0．01)。维生素B12水平与认知功能障碍呈正相关( r =0．441,P <0．01)。结论：叶酸及维生素B12水平与BPSD的认知障碍有关。
목적：탐토협산화유생소 B12여아이자해묵병정신장애( BPSD)적상관성。방법：대77례아이자해묵병( AD)환자( BPSD조40례,비BPSD조37례)급39례정상대조조진행협산화유생소B12측정,병분석기여BPSD급인지공능장애적관계。결과： BPSD조화비BPSD조혈장협산수평명현저우대조조( P<0．05),이BPSD조여비BPSD조미견명현차이(P>0．05)。 BPSD조화비BPSD조혈장유생소B12수평명현저우대조조(P<0．01),차BPSD조현저저우비BPSD조(P<0．01)。유생소B12수평여인지공능장애정정상관( r =0．441,P <0．01)。결론：협산급유생소B12수평여BPSD적인지장애유관。
OBJECTIVE: To investigate the correlation among folate, vitamin B12 and behaviral and psychological symptoms of dementia (BPSD). METHODS: Folate and vitamin B12 were measured in 77 patients with Alzheimer disease (AD). BPSD group was 40 cases, non-BPSD group was 37cases and 39 persons were normal controls. The correlation among folate, vitamin B12 levels, BPSD and cognitive impairment were analyzed. RESULTS: ①The level of folate was significantly lower in BPSD and non -BPSD group than that in the normal group (P<0. 05). But there was no significantly differance in BPSD and non BPSD group (P>0. 05).②The vitamin B12 levels were significantly lower in BPSD and non-BPSD group than that in the normal group, and the level of it in BPSD group was significantly lower than that in non-BPSD group (P<0. 01). There was a positive relation between vitamin B12 lev-els and cognitive decline of dementia ( r =0. 441,P <0. 01). CONCLUTION: The low levels of folate and vitamin B12are related to the disorder of BPSD.