CAJ | 학술논문

不同组织和疾病都存在特异性的生物信号。开发能对这些生物信号响应的磁共振成像(MRI)对比剂，不仅有望增加MRI检测疾病的灵敏度，而且能够对病变产生的信号进行分子成像，提高疾病诊断的准确度。该文详细综述了白蛋白、pH、金属离子、酶、氧化还原以及其他生物分子等响应对比剂的最新进展，对未来的研究方向做了展望。
불동조직화질병도존재특이성적생물신호。개발능대저사생물신호향응적자공진성상(MRI)대비제，불부유망증가MRI검측질병적령민도，이차능구대병변산생적신호진행분자성상，제고질병진단적준학도。해문상세종술료백단백、pH、금속리자、매、양화환원이급기타생물분자등향응대비제적최신진전，대미래적연구방향주료전망。
Different tissues and diseases have specific biological signals. The development of magnetic resonance imaging (MRI) contrast agents responding to these signals can not only improve the sensitivity of disease detection by MRI, but also increase the accuracy of disease diagnosis through molecular imaging of these disease signals. This paper gives a review of MRI contrast agents responding to albumin, pH, metal ion, enzyme, redox and other biological signals with the focus on the latest developments and perspectives.