CAJ | 학술논문

整合素作为细胞黏附受体家族成员，通过双向变构调节信号转导，介导细胞与细胞间以及细胞与细胞外基质间的黏附，并与细胞因子相互作用，参与调节胰腺癌细胞的增殖、凋亡、侵袭、迁移等生物学行为。以整合素为靶点的细胞学和动物研究表明，靶向整合素能有效提高胰腺癌的早期诊断率和药物治疗效果，这些发现为胰腺癌的临床诊治开辟了新的研究途径和发展方向。
정합소작위세포점부수체가족성원，통과쌍향변구조절신호전도，개도세포여세포간이급세포여세포외기질간적점부，병여세포인자상호작용，삼여조절이선암세포적증식、조망、침습、천이등생물학행위。이정합소위파점적세포학화동물연구표명，파향정합소능유효제고이선암적조기진단솔화약물치료효과，저사발현위이선암적림상진치개벽료신적연구도경화발전방향。
Integrins are a family of cell adhesion receptors that mediate cell-cell and cell-extracellular matrix adhesion, and interact with cytokines through a bidirectional signal transduction,thus regulating the biological behavior of pancreatic cancer cells,such as proliferation,apoptosis,invasion,and migration etc. Molecular and animal studies indicated that integrins targeted methods might benefit the early diagnosis and drug therapy of pancreatic cancer,which offered a new approach for the study of diagnosis and treatment of pancreatic cancer.