CAJ | 학술논문

长链非编码RNA（ lncRNAs）是一类长度超过200个核苷酸且无蛋白质编码功能的RNA，能在表观遗传学、转录和转录后水平调控基因表达，广泛参与机体生理和病理过程。近年研究发现lncRNAs在多种消化系统疾病的发生、发展过程中发挥作用，对 lncRNAs的研究将为这些疾病发生的预测、诊断和治疗以及预后评估提供有价值的信息。本文在简要介绍lncRNAs基本概念的基础上，对相关研究进展作一综述。
장련비편마RNA（ lncRNAs）시일류장도초과200개핵감산차무단백질편마공능적RNA，능재표관유전학、전록화전록후수평조공기인표체，엄범삼여궤체생리화병리과정。근년연구발현lncRNAs재다충소화계통질병적발생、발전과정중발휘작용，대 lncRNAs적연구장위저사질병발생적예측、진단화치료이급예후평고제공유개치적신식。본문재간요개소lncRNAs기본개념적기출상，대상관연구진전작일종술。
Long noncoding RNAs( lncRNAs)are a class of non-protein-coding RNA species that are greater than 200 nucleotides in length. LncRNAs regulate gene expression at the epigenetic,transcriptional and post-transcriptional levels, and are widely implicated in the physiological and pathological processes. Recent evidences indicated that lncRNAs play important roles in the development and progression of many digestive system diseases. Studies focusing on lncRNAs may provide valuable data for the prediction,diagnosis,therapeutics and prognosis assessment for these diseases. In this article,the fundamental principles and progress in study on lncRNAs in digestive system diseases were summarized.