CAJ | 학술논문

目的：探讨并比较同步放化疗治疗局部中晚期宫颈癌的临床疗效及不良反应。方法选择初治Ⅱb-Ⅳa期宫颈癌患者120例，按随机数字表法分为同步放化疗组（放化组）60例和单纯放疗组（单放组）60例。观察两组的疗效和副反应，并做比较分析。结果两组近期有效率、5年生存率、局部复发率和远处转移率、胃肠道反应、骨髓抑制反应差异均有统计学意义（P＜0.05）；放射性直肠炎、膀胱炎差异无统计意义（ P＞0.05）。结论同步放化疗能提高局部中晚期宫颈癌近期疗效，提高5年生存率，降低5年的局部复发率、远处转移率，但胃肠道反应及骨髓抑制反应增加明显。
목적：탐토병비교동보방화료치료국부중만기궁경암적림상료효급불량반응。방법선택초치Ⅱb-Ⅳa기궁경암환자120례，안수궤수자표법분위동보방화료조（방화조）60례화단순방료조（단방조）60례。관찰량조적료효화부반응，병주비교분석。결과량조근기유효솔、5년생존솔、국부복발솔화원처전이솔、위장도반응、골수억제반응차이균유통계학의의（P＜0.05）；방사성직장염、방광염차이무통계의의（ P＞0.05）。결론동보방화료능제고국부중만기궁경암근기료효，제고5년생존솔，강저5년적국부복발솔、원처전이솔，단위장도반응급골수억제반응증가명현。
Objective To explore the synchronous chemoradiotherapy of clinical curative effect and adverse reaction of synchronous chemoradiation therapy in the treatment local medium-term and advanced cervical cancer . Methods According to random number table method ,one hundred and twenty patients withⅡb-Ⅳa cervical cancer receiving initial treatment were divide into synchronous chemotherapy group (60 cases) and simple radiotherapy group ( 60 cases ) .Results Between two groups there were statistically significant difference in short-term therapeutic effect,5-years′survival rate,local recurrence rate and distant metastasis rate in 5-year(P<0.05);and there were sta-tistically significant difference in gastrointestinal reaction,bone marrow suppression(P<0.05);no significant differ-ence were observed in the radiation proctitis and radioactive ,cystitis(P>0.05).Conclusion Synchronous chemora-diotherapy can improve short-term therapeutic effect of local medium-term advanced cervical cancer , improve the 5-year survival rate, reduce local recurrence rate and distant metastasis rate in 5-years,but significantly increase the gastrointestinal reaction and bone marrow suppression .