中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2014年
9期
829-831
,共3页
冠状动脉%盐酸替罗非班%急诊经皮冠状动脉介入治疗%急性心肌梗死%慢血流
冠狀動脈%鹽痠替囉非班%急診經皮冠狀動脈介入治療%急性心肌梗死%慢血流
관상동맥%염산체라비반%급진경피관상동맥개입치료%급성심기경사%만혈류
Coronary artery%Tirofiban hydrochloride%Emergency percutaneous coronary intervention (PCI)%Acute myocardial infarction%Slow flow
目的：探讨冠状动脉内注射半剂量替罗非班对老年急诊经皮冠状动脉介入治疗（ PCI ）心肌梗死患者术中慢血流的有效性及安全性。方法98例老年急诊PCI术中出现慢血流的心肌梗死患者，随机分为A组和B组，各49例，分别于冠状动脉内给予5μg/kg和10μg/kg替罗非班，比较两组患者血浆C-反应蛋白、血清肌酸激酶同工酶和心肌肌钙蛋白I、心血管事件和术后3d内出血情况。结果入组时和术后第3天，两组患者血浆C-反应蛋白、血清肌酸激酶同工酶和心肌肌钙蛋白I差异无统计学意义（ P＞0.05）。两组患者主要心血管事件发生率差异无统计学意义（ P＞0.05）。两组患者无血红蛋白、血球压积和血小板计数下降，也未见过敏性反应等。 A组患者出现轻度出血2例（4.08％），B组3例（6.12％），两组比较差异无统计学意义（ P＞0.05）。结论冠状动脉内注射半剂量替罗非班对老年急诊PCI心肌梗死患者术中慢血流临床疗效确切，具有安全高效和不良反应少等优点，值得在临床上推广应用。
目的：探討冠狀動脈內註射半劑量替囉非班對老年急診經皮冠狀動脈介入治療（ PCI ）心肌梗死患者術中慢血流的有效性及安全性。方法98例老年急診PCI術中齣現慢血流的心肌梗死患者，隨機分為A組和B組，各49例，分彆于冠狀動脈內給予5μg/kg和10μg/kg替囉非班，比較兩組患者血漿C-反應蛋白、血清肌痠激酶同工酶和心肌肌鈣蛋白I、心血管事件和術後3d內齣血情況。結果入組時和術後第3天，兩組患者血漿C-反應蛋白、血清肌痠激酶同工酶和心肌肌鈣蛋白I差異無統計學意義（ P＞0.05）。兩組患者主要心血管事件髮生率差異無統計學意義（ P＞0.05）。兩組患者無血紅蛋白、血毬壓積和血小闆計數下降，也未見過敏性反應等。 A組患者齣現輕度齣血2例（4.08％），B組3例（6.12％），兩組比較差異無統計學意義（ P＞0.05）。結論冠狀動脈內註射半劑量替囉非班對老年急診PCI心肌梗死患者術中慢血流臨床療效確切，具有安全高效和不良反應少等優點，值得在臨床上推廣應用。
목적：탐토관상동맥내주사반제량체라비반대노년급진경피관상동맥개입치료（ PCI ）심기경사환자술중만혈류적유효성급안전성。방법98례노년급진PCI술중출현만혈류적심기경사환자，수궤분위A조화B조，각49례，분별우관상동맥내급여5μg/kg화10μg/kg체라비반，비교량조환자혈장C-반응단백、혈청기산격매동공매화심기기개단백I、심혈관사건화술후3d내출혈정황。결과입조시화술후제3천，량조환자혈장C-반응단백、혈청기산격매동공매화심기기개단백I차이무통계학의의（ P＞0.05）。량조환자주요심혈관사건발생솔차이무통계학의의（ P＞0.05）。량조환자무혈홍단백、혈구압적화혈소판계수하강，야미견과민성반응등。 A조환자출현경도출혈2례（4.08％），B조3례（6.12％），량조비교차이무통계학의의（ P＞0.05）。결론관상동맥내주사반제량체라비반대노년급진PCI심기경사환자술중만혈류림상료효학절，구유안전고효화불량반응소등우점，치득재림상상추엄응용。
Objective To explore the safety and efficacy of intracoronary injection of half dose of tirofiban for the slow flow in elderly patients with acute myocardial infarction during emergency percutaneous coronary interven -tion( PCI) operation.Methods Ninety-eight elderly patients with myocardial infarction who had slow flow during e -mergency PCI operation were randomly divided into A group and B group , with 49 cases in each group , and were giv-en 5 μg/kg and 10μg/kg tirofiban in the coronary artery respectively .Between two groups the plasma C-reactive pro-tein, serum creatine kinase MB and cardiac troponin I , cardiovascular events , bleeding with in 3 days after operation were compared .Results Baseline and third day after operation , the two groups had no statistically significant differ-ence in serum C-reactive protein , serum creatine kinase MB and cardiac troponin I ( P>0.05 ) .Two groups had no decrease in hemoglobin , hematocrit and platelet counts , no allergic reaction was found .2 cases of mild bleeding in A group(4.08%), 3 case of mild bleeding in B group (6.12%), no significant difference between two groups (P>0.05 ) .Conclusion Intracoronary injection of half dose of tirofiban has the exact efficacy on slow flow of elderly my -ocardial infarctionin patients undergoing emergency PCI , and is safe and effective with less adverse reaction , and is worth of clinical application .
